<<3(S)-tert-butylsulfonylmethyl>-<2-(1-naphthyl)>-propionyl>-(S)-valinyl-(S)-phenylalaninol diamide

Base Information

Chemical Name:<<3(S)-tert-butylsulfonylmethyl>-<2-(1-naphthyl)>-propionyl>-(S)-valinyl-(S)-phenylalaninol diamide
CAS No.:176692-32-3
Molecular Formula:C₃₂H₄₂N₂O₅S
Molecular Weight:566.762
Hs Code.:

Synonyms:<<3(S)-tert-butylsulfonylmethyl>-<2-(1-naphthyl)>-propionyl>-(S)-valinyl-(S)-phenylalaninol diamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of <<3(S)-tert-butylsulfonylmethyl>-<2-(1-naphthyl)>-propionyl>-(S)-valinyl-(S)-phenylalaninol diamide

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Technology Process of <<3(S)-tert-butylsulfonylmethyl>-<2-(1-naphthyl)>-propionyl>-(S)-valinyl-(S)-phenylalaninol diamide

There total 7 articles about <<3(S)-tert-butylsulfonylmethyl>-<2-(1-naphthyl)>-propionyl>-(S)-valinyl-(S)-phenylalaninol diamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 137331-84-1
(2S)-<3-tert-butylsulfonyl-2-(1-naphthyl)methyl>-propionic acid

: 158009-90-6
(S)-2-amino-N-((S)-1-hydroxy-3-phenylpropan-2-yl)-3-methylbutanamide

: 176692-32-3
<<3(S)-tert-butylsulfonylmethyl>-<2-(1-naphthyl)>-propionyl>-(S)-valinyl-(S)-phenylalaninol diamide

Guidance literature:: With benzotriazol-1-ol; dicyclohexyl-carbodiimide; Ambient temperature;

Reference yield: 74.0%

: 137331-84-1
(2S)-<3-tert-butylsulfonyl-2-(1-naphthyl)methyl>-propionic acid

: (S)-2-Amino-N-((S)-1-hydroxymethyl-2-phenyl-ethyl)-3-methyl-butyramide; hydrochloride

: 176692-32-3
<<3(S)-tert-butylsulfonylmethyl>-<2-(1-naphthyl)>-propionyl>-(S)-valinyl-(S)-phenylalaninol diamide

Guidance literature:: With triethylamine; dicyclohexyl-carbodiimide; In ethyl acetate; at 45 ℃; for 2h;

Reference yield:

: 3182-95-4
L-Phenylalaninol

: 176692-32-3
<<3(S)-tert-butylsulfonylmethyl>-<2-(1-naphthyl)>-propionyl>-(S)-valinyl-(S)-phenylalaninol diamide

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / NEt₃, n-propyl phosphonic acid anhydride / CH₂Cl₂; ethyl acetate / 3 h / 0 - 20 °C

2: 91 percent / HCl gas / methanol / 2 h

3: 74 percent / NEt₃, N,N'-dicyclohexylcarbodiimide / ethyl acetate / 2 h / 45 °C

With hydrogenchloride; propylphosphonic anhydride; triethylamine; dicyclohexyl-carbodiimide; In methanol; dichloromethane; ethyl acetate;