[(S)-3-((S)-2-Amino-3-phenyl-propionylamino)-2-hydroxy-4-methyl-pentanoylamino]-acetic acid methyl ester

Base Information

Chemical Name:[(S)-3-((S)-2-Amino-3-phenyl-propionylamino)-2-hydroxy-4-methyl-pentanoylamino]-acetic acid methyl ester
CAS No.:453509-72-3
Molecular Formula:C₁₈H₂₇N₃O₅
Molecular Weight:365.429
Hs Code.:

Synonyms:[(S)-3-((S)-2-Amino-3-phenyl-propionylamino)-2-hydroxy-4-methyl-pentanoylamino]-acetic acid methyl ester

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Chemical Property of [(S)-3-((S)-2-Amino-3-phenyl-propionylamino)-2-hydroxy-4-methyl-pentanoylamino]-acetic acid methyl ester

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Technology Process of [(S)-3-((S)-2-Amino-3-phenyl-propionylamino)-2-hydroxy-4-methyl-pentanoylamino]-acetic acid methyl ester

There total 4 articles about [(S)-3-((S)-2-Amino-3-phenyl-propionylamino)-2-hydroxy-4-methyl-pentanoylamino]-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 289708-00-5
2-tert-butoxycarbonylamino-3-phenyl-propionic acid 2-tert-butoxycarbonylamino-1-(methoxycarbonylmethyl-carbamoyl)-3-methyl-butyl ester

: 453509-72-3
[(S)-3-((S)-2-Amino-3-phenyl-propionylamino)-2-hydroxy-4-methyl-pentanoylamino]-acetic acid methyl ester

Guidance literature:: 2-tert-butoxycarbonylamino-3-phenyl-propionic acid 2-tert-butoxycarbonylamino-1-(methoxycarbonylmethyl-carbamoyl)-3-methyl-butyl ester; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

With triethylamine; In dichloromethane; for 1h; Further stages.;
DOI:10.1039/b002027n

Reference yield:

: 79069-51-5
(S)-N-tert-butoxycarbonylvalinal

: 453509-72-3
[(S)-3-((S)-2-Amino-3-phenyl-propionylamino)-2-hydroxy-4-methyl-pentanoylamino]-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 95 percent / CH₂Cl₂ / 24 h / 20 °C

2.1: CF₃CO₂H

2.2: Et₃N

With trifluoroacetic acid; In dichloromethane; 1.1: Passerini reaction;
DOI:10.1016/S0040-4039(02)00728-1

Reference yield:

: 13734-41-3
t-Boc-L-valine

: 453509-72-3
[(S)-3-((S)-2-Amino-3-phenyl-propionylamino)-2-hydroxy-4-methyl-pentanoylamino]-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 62 percent / BH₃*Me₂S

2.1: 95 percent / CH₂Cl₂ / 24 h / 20 °C

3.1: CF₃CO₂H

3.2: Et₃N

With dimethylsulfide borane complex; trifluoroacetic acid; In dichloromethane; 2.1: Swern oxidation / 3.1: Passerini reaction;
DOI:10.1016/S0040-4039(02)00728-1