(2S,4R)-4-benzenesulfonyl-2-(1-cyanocyclopropylcarbamoyl)pyrrolidine trifluoroacetic acid

Base Information

Chemical Name:(2S,4R)-4-benzenesulfonyl-2-(1-cyanocyclopropylcarbamoyl)pyrrolidine trifluoroacetic acid
CAS No.:1252632-38-4
Molecular Formula:C₂HF₃O₂*C₁₅H₁₇N₃O₃S
Molecular Weight:433.408
Hs Code.:

Synonyms:(2S,4R)-4-benzenesulfonyl-2-(1-cyanocyclopropylcarbamoyl)pyrrolidine trifluoroacetic acid

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Chemical Property of (2S,4R)-4-benzenesulfonyl-2-(1-cyanocyclopropylcarbamoyl)pyrrolidine trifluoroacetic acid

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Technology Process of (2S,4R)-4-benzenesulfonyl-2-(1-cyanocyclopropylcarbamoyl)pyrrolidine trifluoroacetic acid

There total 6 articles about (2S,4R)-4-benzenesulfonyl-2-(1-cyanocyclopropylcarbamoyl)pyrrolidine trifluoroacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1252632-23-7
(2S,4R)-4-benzenesulfonyl-2-(1-cyanocyclopropylcarbamoyl)-N-Boc-pyrrolidine

: 76-05-1
trifluoroacetic acid

: 1252632-38-4
(2S,4R)-4-benzenesulfonyl-2-(1-cyanocyclopropylcarbamoyl)pyrrolidine trifluoroacetic acid

Guidance literature:: at 22 ℃;

Reference yield:

: 121147-93-1
(2S,4S)-2-methyl N-Boc-4-((methylsulfonyl)oxy)pyrrolidine-2-carboxylate

: 1252632-38-4
(2S,4R)-4-benzenesulfonyl-2-(1-cyanocyclopropylcarbamoyl)pyrrolidine trifluoroacetic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 22 °C

1.2: 50 °C

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 22 °C

3.1: water; lithium hydroxide / tetrahydrofuran; methanol / 22 °C

4.1: isobutyl chloroformate; 4-methyl-morpholine / tetrahydrofuran / 0.5 h / -16 °C

4.2: 22 °C

5.1: dichloromethane / 22 °C

With 4-methyl-morpholine; water; sodium hydride; 3-chloro-benzenecarboperoxoic acid; lithium hydroxide; isobutyl chloroformate; In tetrahydrofuran; methanol; dichloromethane; mineral oil;
DOI:10.1021/jm401528k

Reference yield:

: 74844-91-0,114676-69-6,135042-17-0,227935-38-8,102195-79-9
(2S,4S)-N-tert-butoxycarbonyl-4-hydroxyproline methyl ester

: 1252632-38-4
(2S,4R)-4-benzenesulfonyl-2-(1-cyanocyclopropylcarbamoyl)pyrrolidine trifluoroacetic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / dichloromethane / 5 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 22 °C

2.2: 50 °C

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 22 °C

4.1: water; lithium hydroxide / tetrahydrofuran; methanol / 22 °C

5.1: isobutyl chloroformate; 4-methyl-morpholine / tetrahydrofuran / 0.5 h / -16 °C

5.2: 22 °C

6.1: dichloromethane / 22 °C

With 4-methyl-morpholine; water; sodium hydride; triethylamine; 3-chloro-benzenecarboperoxoic acid; lithium hydroxide; isobutyl chloroformate; In tetrahydrofuran; methanol; dichloromethane; mineral oil;
DOI:10.1021/jm401528k