3<3<4(4-fluorophenyl)piperazinyl>propyl>-6-(2-methylidenebutanoyl)-2(3H)benzoxazolone

Base Information

• Chemical Name: 3<3<4(4-fluorophenyl)piperazinyl>propyl>-6-(2-methylidenebutanoyl)-2(3H)benzoxazolone
• CAS No.: 148101-73-9
• Molecular Formula: C₂₅H₂₈FN₃O₃
• Molecular Weight: 437.514
• Mol file: 148101-73-9.mol

Synonyms:3<3<4(4-fluorophenyl)piperazinyl>propyl>-6-(2-methylidenebutanoyl)-2(3H)benzoxazolone

Chemical Property of 3<3<4(4-fluorophenyl)piperazinyl>propyl>-6-(2-methylidenebutanoyl)-2(3H)benzoxazolone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3<3<4(4-fluorophenyl)piperazinyl>propyl>-6-(2-methylidenebutanoyl)-2(3H)benzoxazolone

There total 1 articles about 3<3<4(4-fluorophenyl)piperazinyl>propyl>-6-(2-methylidenebutanoyl)-2(3H)benzoxazolone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

1,3,5-Trioxan (110-88-3) + 3<3<4(4-Fluorophenyl)piperazinyl>propyl>-6-butanoyl-2(3H)benzoxazolone (148101-72-8) → 3<3<4(4-fluorophenyl)piperazinyl>propyl>-6-(2-methylidenebutanoyl)-2(3H)benzoxazolone (148101-73-9)

Guidance literature:

With morpholin hydrochloride; sodium acetate; In acetic acid; for 5h; Heating;

Reference yield: 59.0%

3<3<4(4-fluorophenyl)piperazinyl>propyl>-6-(2-methylidenebutanoyl)-2(3H)benzoxazolone (148101-73-9) → 3<3<4(4-fluorophenyl)piperazinyl>propyl>-2,3-dihydro-6-ethyl-2,7-dioxocyclopenta(f)benzoxazol (148101-74-0)

Guidance literature:

With sulfuric acid; for 18h; Ambient temperature;

Reference yield:

3<3<4(4-fluorophenyl)piperazinyl>propyl>-6-(2-methylidenebutanoyl)-2(3H)benzoxazolone (148101-73-9) → 6-Ethyl-3-{3-[4-(4-fluoro-phenyl)-piperazin-1-yl]-propyl}-3,5,6,7-tetrahydro-indeno[5,6-d]oxazol-2-one

Guidance literature:

Multi-step reaction with 2 steps

1: 59 percent / conc. H₂SO₄ / 18 h / Ambient temperature

2: 57 percent / triethyl silane, trifluoroacetic acid / 72 h / Ambient temperature

With triethylsilane; sulfuric acid; trifluoroacetic acid;

upstream raw materials:

1,3,5-Trioxan

3<3<4(4-Fluorophenyl)piperazinyl>propyl>-6-butanoyl-2(3H)benzoxazolone

Downstream raw materials:

3<3<4(4-fluorophenyl)piperazinyl>propyl>-2,3-dihydro-6-ethyl-2,7-dioxocyclopenta(f)benzoxazol