(1S,4S)-1-[2-((4aS,5S,6S,8aS)-6-tert-Butoxy-2,2,5-trimethyl-hexahydro-benzo[1,3]dioxin-5-yl)-1-methoxymethoxy-ethyl]-4-(tert-butyl-dimethyl-silanyloxy)-2,6,6-trimethyl-cyclohex-2-enol

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Chemical Name:(1S,4S)-1-[2-((4aS,5S,6S,8aS)-6-tert-Butoxy-2,2,5-trimethyl-hexahydro-benzo[1,3]dioxin-5-yl)-1-methoxymethoxy-ethyl]-4-(tert-butyl-dimethyl-silanyloxy)-2,6,6-trimethyl-cyclohex-2-enol
CAS No.:208577-88-2
Molecular Formula:C₃₄H₆₄O₇Si
Molecular Weight:612.963
Hs Code.:

(1S,4S)-1-[2-((4aS,5S,6S,8aS)-6-tert-Butoxy-2,2,5-trimethyl-hexahydro-benzo[1,3]dioxin-5-yl)-1-methoxymethoxy-ethyl]-4-(tert-butyl-dimethyl-silanyloxy)-2,6,6-trimethyl-cyclohex-2-enol

Synonyms:(1S,4S)-1-[2-((4aS,5S,6S,8aS)-6-tert-Butoxy-2,2,5-trimethyl-hexahydro-benzo[1,3]dioxin-5-yl)-1-methoxymethoxy-ethyl]-4-(tert-butyl-dimethyl-silanyloxy)-2,6,6-trimethyl-cyclohex-2-enol

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Chemical Property of (1S,4S)-1-[2-((4aS,5S,6S,8aS)-6-tert-Butoxy-2,2,5-trimethyl-hexahydro-benzo[1,3]dioxin-5-yl)-1-methoxymethoxy-ethyl]-4-(tert-butyl-dimethyl-silanyloxy)-2,6,6-trimethyl-cyclohex-2-enol

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Technology Process of (1S,4S)-1-[2-((4aS,5S,6S,8aS)-6-tert-Butoxy-2,2,5-trimethyl-hexahydro-benzo[1,3]dioxin-5-yl)-1-methoxymethoxy-ethyl]-4-(tert-butyl-dimethyl-silanyloxy)-2,6,6-trimethyl-cyclohex-2-enol

There total 2 articles about (1S,4S)-1-[2-((4aS,5S,6S,8aS)-6-tert-Butoxy-2,2,5-trimethyl-hexahydro-benzo[1,3]dioxin-5-yl)-1-methoxymethoxy-ethyl]-4-(tert-butyl-dimethyl-silanyloxy)-2,6,6-trimethyl-cyclohex-2-enol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 155095-85-5
2-((4aS,5S,6S,8aS)-6-tert-Butoxy-2,2,5-trimethyl-hexahydro-benzo[1,3]dioxin-5-yl)-ethanol

: 208577-88-2
(1S,4S)-1-[2-((4aS,5S,6S,8aS)-6-tert-Butoxy-2,2,5-trimethyl-hexahydro-benzo[1,3]dioxin-5-yl)-1-methoxymethoxy-ethyl]-4-(tert-butyl-dimethyl-silanyloxy)-2,6,6-trimethyl-cyclohex-2-enol

Guidance literature:: Multi-step reaction with 2 steps

1: DMSO, (COCl)2, Et₃N / CH₂Cl₂ / -60 °C

2: 1.) Bu₃SnLi; 2.) MOMCl, iPr₂NEt; 3.) nBuLi / 1.)THF, -70 deg C; 2.) CH₂Cl₂, rt; 3.) THF, -70 deg C, 10 min

With n-butyllithium; oxalyl dichloride; tri-n-butyltin lithium; chloromethyl methyl ether; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1016/S0040-4039(98)00600-5

Reference yield:

: 155095-86-6
((4aS,5S,6S,8aS)-6-tert-Butoxy-2,2,5-trimethyl-hexahydro-benzo[1,3]dioxin-5-yl)-acetaldehyde

: (+/-) 4-[(tert-butyldimethylsilyl)oxy]-2,6,6-trimethylcyclohex-2-en-1-one

: 208577-88-2
(1S,4S)-1-[2-((4aS,5S,6S,8aS)-6-tert-Butoxy-2,2,5-trimethyl-hexahydro-benzo[1,3]dioxin-5-yl)-1-methoxymethoxy-ethyl]-4-(tert-butyl-dimethyl-silanyloxy)-2,6,6-trimethyl-cyclohex-2-enol

Guidance literature:: With n-butyllithium; tri-n-butyltin lithium; chloromethyl methyl ether; N-ethyl-N,N-diisopropylamine; Yield given. Multistep reaction; 1.)THF, -70 deg C; 2.) CH₂Cl₂, rt; 3.) THF, -70 deg C, 10 min;
DOI:10.1016/S0040-4039(98)00600-5