(2S,5R,6R)-7-Oxo-6-phenylacetylamino-3-thioxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid tert-butyl ester

Base Information

Chemical Name:(2S,5R,6R)-7-Oxo-6-phenylacetylamino-3-thioxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid tert-butyl ester
CAS No.:87035-93-6
Molecular Formula:C₁₈H₂₀N₂O₄S₂
Molecular Weight:392.5
Hs Code.:

Synonyms:(2S,5R,6R)-7-Oxo-6-phenylacetylamino-3-thioxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid tert-butyl ester

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Chemical Property of (2S,5R,6R)-7-Oxo-6-phenylacetylamino-3-thioxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid tert-butyl ester

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Technology Process of (2S,5R,6R)-7-Oxo-6-phenylacetylamino-3-thioxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid tert-butyl ester

There total 4 articles about (2S,5R,6R)-7-Oxo-6-phenylacetylamino-3-thioxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 87035-92-5,87044-35-7
(5R,6R)-7-Oxo-6-phenylacetylamino-3-thioxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2,2-dicarboxylic acid tert-butyl ester 4-nitro-benzyl ester

: 87035-93-6
(2S,5R,6R)-7-Oxo-6-phenylacetylamino-3-thioxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid tert-butyl ester

Guidance literature:: With hydrogen; 10% palladium on active carbon; In ethyl acetate; at 20 ℃;
DOI:10.1016/S0040-4039(00)81982-6

Reference yield:

: 2-Bromo-malonic acid tert-butyl ester 3-nitro-benzyl ester

: 87035-93-6
(2S,5R,6R)-7-Oxo-6-phenylacetylamino-3-thioxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 65 percent / Triton B / dimethylformamide / -30 deg C to 20 deg C

2: 35percent HClO₄ / methanol / 0.5 h / 20 °C

3: 59 percent / triethylamine / CH₂Cl₂ / -60 deg C to 0 deg C

4: 35 percent / hydrogen / Pd 10percent on C / ethyl acetate / 20 °C

With perchloric acid; hydrogen; N-benzyl-trimethylammonium hydroxide; triethylamine; 10% palladium on active carbon; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)81982-6

Reference yield:

: 78833-85-9,78856-78-7
2-<3-benzyl-6-oxo-2-thia-4,7-diaza-(1R,5R)-bicyclo-<3.2.0>-hept-3-en-7-yl>-t-butyl and p-nitrobenzyl malonate

: 87035-93-6
(2S,5R,6R)-7-Oxo-6-phenylacetylamino-3-thioxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 35percent HClO₄ / methanol / 0.5 h / 20 °C

2: 59 percent / triethylamine / CH₂Cl₂ / -60 deg C to 0 deg C

3: 35 percent / hydrogen / Pd 10percent on C / ethyl acetate / 20 °C

With perchloric acid; hydrogen; triethylamine; 10% palladium on active carbon; In methanol; dichloromethane; ethyl acetate;
DOI:10.1016/S0040-4039(00)81982-6