N-(1-(4-(3-(2-chloroethyl)ureido)benzyl)piperidin-4-yl)-3-(trifluoromethyl)benzamide

Base Information

Chemical Name:N-(1-(4-(3-(2-chloroethyl)ureido)benzyl)piperidin-4-yl)-3-(trifluoromethyl)benzamide
CAS No.:1637586-48-1
Molecular Formula:C₂₃H₂₆ClF₃N₄O₂
Molecular Weight:482.933
Hs Code.:

Synonyms:N-(1-(4-(3-(2-chloroethyl)ureido)benzyl)piperidin-4-yl)-3-(trifluoromethyl)benzamide

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Chemical Property of N-(1-(4-(3-(2-chloroethyl)ureido)benzyl)piperidin-4-yl)-3-(trifluoromethyl)benzamide

Chemical Property:

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Technology Process of N-(1-(4-(3-(2-chloroethyl)ureido)benzyl)piperidin-4-yl)-3-(trifluoromethyl)benzamide

There total 6 articles about N-(1-(4-(3-(2-chloroethyl)ureido)benzyl)piperidin-4-yl)-3-(trifluoromethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.4%

: 1943-83-5
2-chloroethyl isothiocyanate

: 1637586-36-7
N-(1-(4-aminobenzyl)piperidin-4-yl)-3-(trifluoromethyl)benzamide

: 1637586-48-1
N-(1-(4-(3-(2-chloroethyl)ureido)benzyl)piperidin-4-yl)-3-(trifluoromethyl)benzamide

Guidance literature:: In dichloromethane; at 20 ℃;
DOI:10.3390/molecules19056163

Reference yield:

: 100-11-8
1-bromomethyl-4-nitro-benzene

: 1637586-48-1
N-(1-(4-(3-(2-chloroethyl)ureido)benzyl)piperidin-4-yl)-3-(trifluoromethyl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / acetone / 4 h / 60 °C

2: dichloromethane / 3 h / 0 - 20 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 14 h / 20 °C

4: tin(II) chloride dihdyrate / water; ethanol / 1.5 h / 80 °C

5: dichloromethane / 20 °C

With dmap; tin(II) chloride dihdyrate; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; dichloromethane; water; acetone;
DOI:10.3390/molecules19056163

Reference yield:

: 1637586-32-3
C₂₀H₂₀F₃N₃O₃

: 1637586-48-1
N-(1-(4-(3-(2-chloroethyl)ureido)benzyl)piperidin-4-yl)-3-(trifluoromethyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: tin(II) chloride dihdyrate / water; ethanol / 1.5 h / 80 °C

2: dichloromethane / 20 °C

With tin(II) chloride dihdyrate; In ethanol; dichloromethane; water;
DOI:10.3390/molecules19056163