2-(8-chloro-2-methyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)-1-phenylethanol

Base Information

Chemical Name:2-(8-chloro-2-methyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)-1-phenylethanol
CAS No.:1566527-79-4
Molecular Formula:C₂₀H₂₁ClN₂O
Molecular Weight:340.853
Hs Code.:

Synonyms:2-(8-chloro-2-methyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)-1-phenylethanol

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Chemical Property of 2-(8-chloro-2-methyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)-1-phenylethanol

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Technology Process of 2-(8-chloro-2-methyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)-1-phenylethanol

There total 3 articles about 2-(8-chloro-2-methyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)-1-phenylethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.4%

: 96-09-3
styrene oxide

: 17223-45-9
8-chloro-2-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole

: 1566527-79-4
2-(8-chloro-2-methyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)-1-phenylethanol

Guidance literature:: 8-chloro-2-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h;

styrene oxide; In N,N-dimethyl-formamide; at 45 ℃;
DOI:10.1021/ml400492t

Reference yield:

: 41979-39-9
4-piperidone hydrochloride

: 1566527-79-4
2-(8-chloro-2-methyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)-1-phenylethanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / ethanol / 2 h / Reflux

2.1: sulfuric acid / 1,4-dioxane / 3 h / 80 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 20 °C

3.2: 45 °C

With sulfuric acid; sodium hydride; potassium carbonate; In 1,4-dioxane; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/ml400492t

Reference yield:

: 1445-73-4
1-Methyl-4-piperidone

: 1566527-79-4
2-(8-chloro-2-methyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)-1-phenylethanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: sulfuric acid / 1,4-dioxane / 3 h / 80 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 20 °C

2.2: 45 °C

With sulfuric acid; sodium hydride; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1021/ml400492t