2-Methoxy-1-naphthaldehyde oxime

Base Information

• Chemical Name: 2-Methoxy-1-naphthaldehyde oxime
• CAS No.: 99806-91-4
• Molecular Formula: C12H11 N O2
• Molecular Weight: 201.225
• Hs Code.: 2928000090
• DSSTox Substance ID: DTXSID20425978
• ChEMBL ID: CHEMBL3196222
• Mol file: 99806-91-4.mol

Synonyms:2-methoxy-1-naphthaldehyde oxime;99806-91-4;N-[(2-methoxynaphthalen-1-yl)methylidene]hydroxylamine;SMR000063017;MLS000057970;CHEMBL3196222;SCHEMBL10724211;DTXSID20425978;STK062641;AKOS000485729;2-METHOXY-1-NAPHTHALDEHYDEOXIME;EN300-15703;SR-01000311654;SR-01000311654-1;Z49568555;(E)-N-hydroxy-1-(2-methoxynaphthalen-1-yl)methanimine;(E)-N-[(2-methoxynaphthalen-1-yl)methylidene]hydroxylamine

Chemical Property of 2-Methoxy-1-naphthaldehyde oxime

Chemical Property:

• Vapor Pressure: 4.2E-06mmHg at 25°C
• Refractive Index: 1.569
• Boiling Point: 369.2°Cat760mmHg
• Flash Point: 177.1°C
• PSA: 41.82000
• Density: 1.14g/cm³
• LogP: 2.65650
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 201.078978594
• Heavy Atom Count: 15
• Complexity: 230

Purity/Quality:

N-[(2-methoxynaphthalen-1-yl)methylidene]hydroxylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C2=CC=CC=C2C=C1)C=NO
• Isomeric SMILES: COC1=C(C2=CC=CC=C2C=C1)/C=N/O

Technology Process of 2-Methoxy-1-naphthaldehyde oxime

There total 5 articles about 2-Methoxy-1-naphthaldehyde oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C14H16NO(1+)*CF3O3S(1-) → 2‐methoxy‐1‐naphthaldoxime (99806-91-4)

Guidance literature:

With hydroxylamine hydrochloride; potassium carbonate; In water; 1,2-dichloro-ethane; acetonitrile; at 20 ℃; for 19h;

DOI:10.1016/j.tet.2020.131255

Reference yield:

2-methoxy-1-naphthaldehyde (5392-12-1) → 2‐methoxy‐1‐naphthaldoxime (99806-91-4)

Guidance literature:

With hydroxylamine hydrochloride; sodium acetate; In ethanol; for 12h;

DOI:10.1016/S0960-894X(03)00130-6

Reference yield:

2-Methoxynaphthalene (93-04-9) → 2‐methoxy‐1‐naphthaldoxime (99806-91-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 1,2-dichloro-ethane / 4 h / 80 °C / Inert atmosphere

2: hydroxylamine hydrochloride; potassium carbonate / 1,2-dichloro-ethane; acetonitrile; water / 19 h / 20 °C

With hydroxylamine hydrochloride; potassium carbonate; In water; 1,2-dichloro-ethane; acetonitrile; 1: |Vilsmeier-Haack Formylation;

DOI:10.1016/j.tet.2020.131255

upstream raw materials:

2-methoxy-1-naphthaldehyde

2-Methoxynaphthalene

water

Downstream raw materials:

1-cyano-2-methoxynaphthalene

2-Methoxynaphthalene

1-aminomethyl-2-methoxynaphthalene