Technology Process of (S)-N-phenyl-N-[2-(1-propylpiperidin-2-yl)ethyl]indan-2-yl-amine
There total 12 articles about (S)-N-phenyl-N-[2-(1-propylpiperidin-2-yl)ethyl]indan-2-yl-amine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(S)-2-N-phenyl-N-[2-(piperidin-2-yl)ethyl]indan-2-ylamine;
With
sodium cyanoborohydride;
In
methanol;
at 20 ℃;
for 0.5h;
Cooling with ice;
propionaldehyde;
In
methanol;
at 20 ℃;
for 16h;
Cooling with ice;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 16 h / 20 °C / Cooling with ice
2.1: sodium amide / toluene / 3 h / 20 °C / Cooling with ice
2.2: 16 h / 110 °C / Cooling with ice
3.1: ammonium formate / palladium 10% on activated carbon / methanol / 3 h / 100 °C / Inert atmosphere
4.1: sodium cyanoborohydride / methanol / 0.5 h / 20 °C / Cooling with ice
4.2: 16 h / 20 °C / Cooling with ice
With
ammonium formate; sodium tris(acetoxy)borohydride; sodium cyanoborohydride; sodium amide; acetic acid;
palladium 10% on activated carbon;
In
methanol; dichloromethane; toluene;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 16 h / 20 °C / Cooling with ice
2.1: sodium amide / toluene / 3 h / 20 °C / Cooling with ice
2.2: 16 h / 110 °C / Cooling with ice
3.1: ammonium formate / palladium 10% on activated carbon / methanol / 3 h / 100 °C / Inert atmosphere
4.1: sodium cyanoborohydride / methanol / 0.5 h / 20 °C / Cooling with ice
4.2: 16 h / 20 °C / Cooling with ice
With
ammonium formate; sodium tris(acetoxy)borohydride; sodium cyanoborohydride; sodium amide; acetic acid;
palladium 10% on activated carbon;
In
methanol; dichloromethane; toluene;