benzyl 4--2-(hydroxymethyl)propionyl>amino>butylate

Base Information

• Chemical Name: benzyl 4--2-(hydroxymethyl)propionyl>amino>butylate
• CAS No.: 158665-25-9
• Molecular Formula: C₃₇H₄₁NO₇
• Molecular Weight: 611.735
• Mol file: 158665-25-9.mol

Synonyms:benzyl 4--2-(hydroxymethyl)propionyl>amino>butylate

Chemical Property of benzyl 4--2-(hydroxymethyl)propionyl>amino>butylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of benzyl 4--2-(hydroxymethyl)propionyl>amino>butylate

There total 3 articles about benzyl 4--2-(hydroxymethyl)propionyl>amino>butylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

4,4'-dimethoxytrityl chloride (40615-36-9) + benzyl 4-amino>butylate (158665-24-8) → benzyl 4--2-(hydroxymethyl)propionyl>amino>butylate (158665-25-9)

Guidance literature:

With pyridine; dmap; In dichloromethane; for 12h; Ambient temperature;

DOI:10.1016/S0040-4039(00)78208-6

Reference yield:

2,2-bis(hydroxymethyl)propionic acid (4767-03-7) → benzyl 4--2-(hydroxymethyl)propionyl>amino>butylate (158665-25-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 63 percent / EDCI, HOBt, Et₃N / dimethylformamide / 12 h / Ambient temperature

2: 59 percent / DMAP / pyridine / 12 h

With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In pyridine; N,N-dimethyl-formamide;

DOI:10.1021/jo9611780

Reference yield:

benzyl 4-aminobutanoate (46347-99-3) → benzyl 4--2-(hydroxymethyl)propionyl>amino>butylate (158665-25-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 63 percent / EDCI, HOBt, Et₃N / dimethylformamide / 12 h / Ambient temperature

2: 59 percent / DMAP / pyridine / 12 h

With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In pyridine; N,N-dimethyl-formamide;

DOI:10.1021/jo9611780

upstream raw materials:

4,4'-dimethoxytrityl chloride

benzyl 4-amino>butylate

2,2-bis(hydroxymethyl)propionic acid

benzyl 4-aminobutanoate