2-amido-N-<4-chloro-2-(2,6-dichlorobenzoyl)phenyl>-N-methylacetamide hydrochloride

Base Information

Chemical Name:2-amido-N-<4-chloro-2-(2,6-dichlorobenzoyl)phenyl>-N-methylacetamide hydrochloride
CAS No.:82082-40-4
Molecular Formula:C₁₆H₁₃Cl₃N₂O₂*ClH
Molecular Weight:408.111
Hs Code.:

Synonyms:2-amido-N-<4-chloro-2-(2,6-dichlorobenzoyl)phenyl>-N-methylacetamide hydrochloride

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Chemical Property of 2-amido-N-<4-chloro-2-(2,6-dichlorobenzoyl)phenyl>-N-methylacetamide hydrochloride

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Technology Process of 2-amido-N-<4-chloro-2-(2,6-dichlorobenzoyl)phenyl>-N-methylacetamide hydrochloride

There total 10 articles about 2-amido-N-<4-chloro-2-(2,6-dichlorobenzoyl)phenyl>-N-methylacetamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 82082-38-0
2-azido-N-<4-chloro-2-(2,6-dichlorobenzoyl)phenyl>-N-methylacetamide

: 82082-40-4
2-amido-N-<4-chloro-2-(2,6-dichlorobenzoyl)phenyl>-N-methylacetamide hydrochloride

Guidance literature:: With hydrogenchloride; hydrogen; platinum(IV) oxide; In ethanol; for 3h; under 760 Torr;
DOI:10.1021/jm00351a009

Reference yield:

: 6628-86-0
5-chloro-2-nitrobenzaldehyde

: 82082-40-4
2-amido-N-<4-chloro-2-(2,6-dichlorobenzoyl)phenyl>-N-methylacetamide hydrochloride

Guidance literature:: Multi-step reaction with 9 steps

1: 1.) n-BuLi / 1.) THF, -78 deg C, 20 min, 2.) THF, -78 deg C, 1 h

2: Jones reagent, acetic acid / diethyl ether / 12 h / Ambient temperature

3: 62 percent / H₂ / Raney nickel / ethanol / 8 h / 760 Torr

4: 88 percent / pyridine / 1.33 h / Heating

5: 1.) MeONa / 1.) MeOH, RT, 1 h , 2.) DMF, 4 h

6: 91 percent / 70percent aq. H₂SO₄ / 2 h / 100 °C

7: 91.5 percent / benzene / 1 h / Heating

8: 91 percent / sodium azide / dimethylformamide / 4 h / Heating

9: 94 percent / H₂, conc. HCl / PtO₂ / ethanol / 3 h / 760 Torr

With pyridine; hydrogenchloride; n-butyllithium; sodium azide; jones reagent; sulfuric acid; hydrogen; sodium methylate; acetic acid; platinum(IV) oxide; nickel; In diethyl ether; ethanol; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm00351a009

Reference yield:

: 82082-26-6
(2,6-dichlorophenyl)(2-amino-5-chlorophenyl)methanone

: 82082-40-4
2-amido-N-<4-chloro-2-(2,6-dichlorobenzoyl)phenyl>-N-methylacetamide hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: 88 percent / pyridine / 1.33 h / Heating

2: 1.) MeONa / 1.) MeOH, RT, 1 h , 2.) DMF, 4 h

3: 91 percent / 70percent aq. H₂SO₄ / 2 h / 100 °C

4: 91.5 percent / benzene / 1 h / Heating

5: 91 percent / sodium azide / dimethylformamide / 4 h / Heating

6: 94 percent / H₂, conc. HCl / PtO₂ / ethanol / 3 h / 760 Torr

With pyridine; hydrogenchloride; sodium azide; sulfuric acid; hydrogen; sodium methylate; platinum(IV) oxide; In ethanol; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm00351a009