1,3-Benzodioxole-2-methanamine

Base Information

• Chemical Name: 1,3-Benzodioxole-2-methanamine
• CAS No.: 936-78-7
• Molecular Formula: C₈H₉NO₂
• Molecular Weight: 151.165
• Hs Code.: 2932999099
• Mol file: 936-78-7.mol

Synonyms:1,3-Benzodioxole-2-methylamine(7CI,8CI); Acetaldehyde, amino-, cyclic o-phenylene acetal;[(Benzodioxol-2-yl)methyl]amine

Chemical Property of 1,3-Benzodioxole-2-methanamine

Chemical Property:

• PSA: 44.48000
• LogP: 1.44290

Purity/Quality:

99%min ^*data from raw suppliers

2-(Aminomethyl)-1,3-benzodioxole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,3-Benzodioxole-2-methanamine

There total 4 articles about 1,3-Benzodioxole-2-methanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzo[1,3]dioxole-2-carboxamide (939-71-9) → N-(benzo[1,3]dioxol-2-yl)methylamine (936-78-7)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 23 ℃; for 24h;

DOI:10.1021/jm040124c

Reference yield:

benzene-1,2-diol (120-80-9,19481-10-8,37349-32-9) → N-(benzo[1,3]dioxol-2-yl)methylamine (936-78-7)

Guidance literature:

Multi-step reaction with 3 steps

1: NaOMe / methanol / Heating

2: aq. NH₃ / acetonitrile / 2 h / 23 °C

3: LiAlH₄ / tetrahydrofuran / 24 h / 23 °C

With ammonium hydroxide; lithium aluminium tetrahydride; sodium methylate; In tetrahydrofuran; methanol; acetonitrile;

DOI:10.1021/jm040124c

Reference yield:

methyl benzo[1,3]dioxole-2-carboxylate (57984-85-7) → N-(benzo[1,3]dioxol-2-yl)methylamine (936-78-7)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NH₃ / acetonitrile / 2 h / 23 °C

2: LiAlH₄ / tetrahydrofuran / 24 h / 23 °C

With ammonium hydroxide; lithium aluminium tetrahydride; In tetrahydrofuran; acetonitrile;

DOI:10.1021/jm040124c

upstream raw materials:

benzo[1,3]dioxole-2-carboxamide

benzene-1,2-diol

methyl benzo[1,3]dioxole-2-carboxylate

Refernces

• 1、 -. "USE OF BENZO-FUSED HETEROCYLE SULFAMIDE DERIVATIVES FOR THE TREATMENT OF ANXIETY". Page/Page column 15. . Retrieved 2009/10/06.
• 2、 -. "USE OF BENZO-FUSED HETEROCYCLE SULFAMIDE DERIVATIVES FOR DISEASE MODIFICATION / EPILEPTOGENESIS". Page/Page column 20. . Retrieved 2008/06/13.