[(7S)-7-(3,4-dichlorophenyl)-1,4-oxazepan-7-yl]methanol monohydrochloride

Base Information

Chemical Name:[(7S)-7-(3,4-dichlorophenyl)-1,4-oxazepan-7-yl]methanol monohydrochloride
CAS No.:1372180-12-5
Molecular Formula:C₁₂H₁₅Cl₂NO₂*ClH
Molecular Weight:312.624
Hs Code.:

Synonyms:[(7S)-7-(3,4-dichlorophenyl)-1,4-oxazepan-7-yl]methanol monohydrochloride

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Chemical Property of [(7S)-7-(3,4-dichlorophenyl)-1,4-oxazepan-7-yl]methanol monohydrochloride

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Technology Process of [(7S)-7-(3,4-dichlorophenyl)-1,4-oxazepan-7-yl]methanol monohydrochloride

There total 12 articles about [(7S)-7-(3,4-dichlorophenyl)-1,4-oxazepan-7-yl]methanol monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1372189-48-4
tert-butyl (7S)-7-(3,4-dichlorophenyl)-7-(hydroxymethyl)-1,4-oxazepane-4-carboxylate

: 1372180-12-5
[(7S)-7-(3,4-dichlorophenyl)-1,4-oxazepan-7-yl]methanol monohydrochloride

Guidance literature:: With hydrogenchloride; In ethyl acetate; at 20 ℃;
DOI:10.1016/j.bmc.2015.05.017

Reference yield:

: 1372186-65-6
N-benzyl-2-chloro-N-[3-(3,4-dichlorophenyl)-3-hydroxy-4-(4-methoxyphenoxy)butyl]acetamide

: 1372180-12-5
[(7S)-7-(3,4-dichlorophenyl)-1,4-oxazepan-7-yl]methanol monohydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium t-butanolate / tetrahydrofuran / 16 h / 0 - 35 °C

2.1: lithium aluminium tetrahydride; aluminum (III) chloride / diethyl ether / 2.25 h / 0 - 35 °C

2.2: Cooling with ice

3.1: carbonochloridic acid 1-chloro-ethyl ester / acetonitrile / 2.5 h / 90 °C

3.2: 1 h / 80 °C

3.3: 1.5 h / 10 - 35 °C

4.1: water; ammonium cerium (IV) nitrate / acetonitrile / 0.5 h / 0 °C

5.1: CHIRALPAK AD-H / isopropyl alcohol; carbon dioxide / Resolution of racemate

6.1: hydrogenchloride / ethyl acetate; ethanol

With hydrogenchloride; aluminum (III) chloride; lithium aluminium tetrahydride; ammonium cerium (IV) nitrate; carbonochloridic acid 1-chloro-ethyl ester; water; sodium t-butanolate; In tetrahydrofuran; diethyl ether; ethanol; carbon dioxide; ethyl acetate; isopropyl alcohol; acetonitrile;

Reference yield:

: 1372186-66-7
4-(benzylamino)-2-(3,4-dichlorophenyl)-1-(4-methoxyphenoxy)butan-2-ol

: 1372180-12-5
[(7S)-7-(3,4-dichlorophenyl)-1,4-oxazepan-7-yl]methanol monohydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / tetrahydrofuran / 2.17 h / 0 - 35 °C

2.1: sodium t-butanolate / tetrahydrofuran / 16 h / 0 - 35 °C

3.1: lithium aluminium tetrahydride; aluminum (III) chloride / diethyl ether / 2.25 h / 0 - 35 °C

3.2: Cooling with ice

4.1: carbonochloridic acid 1-chloro-ethyl ester / acetonitrile / 2.5 h / 90 °C

4.2: 1 h / 80 °C

4.3: 1.5 h / 10 - 35 °C

5.1: water; ammonium cerium (IV) nitrate / acetonitrile / 0.5 h / 0 °C

6.1: CHIRALPAK AD-H / isopropyl alcohol; carbon dioxide / Resolution of racemate

7.1: hydrogenchloride / ethyl acetate; ethanol

With hydrogenchloride; aluminum (III) chloride; lithium aluminium tetrahydride; ammonium cerium (IV) nitrate; carbonochloridic acid 1-chloro-ethyl ester; water; triethylamine; sodium t-butanolate; In tetrahydrofuran; diethyl ether; ethanol; carbon dioxide; ethyl acetate; isopropyl alcohol; acetonitrile;