3,5-difluoro-N-(1-methyl-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-3-carbonothioyl) benzamide

Base Information

Chemical Name:3,5-difluoro-N-(1-methyl-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-3-carbonothioyl) benzamide
CAS No.:1629888-40-9
Molecular Formula:C₁₇H₁₁F₂N₃O₃S
Molecular Weight:375.355
Hs Code.:

Synonyms:3,5-difluoro-N-(1-methyl-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-3-carbonothioyl) benzamide

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Chemical Property of 3,5-difluoro-N-(1-methyl-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-3-carbonothioyl) benzamide

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Technology Process of 3,5-difluoro-N-(1-methyl-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-3-carbonothioyl) benzamide

There total 2 articles about 3,5-difluoro-N-(1-methyl-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-3-carbonothioyl) benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1629888-39-6
1-methyl-2,4-dioxo-1,2-dihydroquinazoline-3(4H)-carbothioamide

: 129714-97-2
3,5-difluorobenzoyl chloride

: 1629888-40-9
3,5-difluoro-N-(1-methyl-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-3-carbonothioyl) benzamide

Guidance literature:: 1-methyl-2,4-dioxo-1,2-dihydroquinazoline-3(4H)-carbothioamide; With triethylamine; In N,N-dimethyl-formamide; at 0 - 5 ℃; for 0.5h;

3,5-difluorobenzoyl chloride; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.2174/1570180811666131230235157

Reference yield:

: 119-68-6
N-Methylanthranilic acid

: 1629888-40-9
3,5-difluoro-N-(1-methyl-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-3-carbonothioyl) benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: Alkaline conditions

2.1: hydrogenchloride / water / 0.5 h / Reflux

2.2: 4 h / Reflux

3.1: triethylamine / N,N-dimethyl-formamide / 0.5 h / 0 - 5 °C

3.2: 20 °C

With hydrogenchloride; triethylamine; In water; N,N-dimethyl-formamide;
DOI:10.2174/1570180811666131230235157