2-Chloro-1-cyclopentylethanone

Base Information

• Chemical Name: 2-Chloro-1-cyclopentylethanone
• CAS No.: 932-28-5
• Molecular Formula: C7H11ClO
• Molecular Weight: 146.617
• Hs Code.: 2914700090
• DSSTox Substance ID: DTXSID70499381
• Wikidata: Q72518096
• Mol file: 932-28-5.mol

Synonyms:2-CHLORO-1-CYCLOPENTYLETHANONE;932-28-5;2-Chloro-1-cyclopentylethan-1-one;Ethanone, 2-chloro-1-cyclopentyl- (9CI);Chloromethyl cyclopentyl ketone;2-chloro-1-cyclopentyl-ethanone;SCHEMBL3990466;AMY7275;DTXSID70499381;ZKYWWOXZNCTARW-UHFFFAOYSA-N;AKOS006314747;CS-0238161;FT-0761504;EN300-190882;Z1198266546

Chemical Property of 2-Chloro-1-cyclopentylethanone

Chemical Property:

• Boiling Point: 205.1 °C at 760 mmHg
• Flash Point: 92.8 °C
• PSA: 17.07000
• Density: 1.116 g/cm³
• LogP: 1.98450
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 146.0498427
• Heavy Atom Count: 9
• Complexity: 106

Purity/Quality:

98%min ^*data from raw suppliers

2-Chloro-1-cyclopentylethanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCC(C1)C(=O)CCl

Technology Process of 2-Chloro-1-cyclopentylethanone

There total 11 articles about 2-Chloro-1-cyclopentylethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

Cyclopentanecarboxylic acid chloride (4524-93-0) + diazomethyl-trimethyl-silane (18107-18-1) → 2-chloro-1-cyclopentylethan-1-one (932-28-5)

Guidance literature:

Cyclopentanecarboxylic acid chloride; diazomethyl-trimethyl-silane; In tetrahydrofuran; hexanes; at 0 - 20 ℃; for 12h;

With hydrogenchloride; In tetrahydrofuran; 1,4-dioxane; at 24 ℃; for 2h;

Reference yield: 67.0%

Cyclopentanecarboxylic acid chloride (4524-93-0) + (diazomethyl)-trimethylsilane → 2-chloro-1-cyclopentylethan-1-one (932-28-5)

Guidance literature:

Cyclopentanecarboxylic acid chloride; (diazomethyl)-trimethylsilane; In tetrahydrofuran; at 0 - 20 ℃; for 12h;

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 2h;

Reference yield:

1-Cyclopentyl-2-diazo-1-ethanone (35964-12-6) → 2-chloro-1-cyclopentylethan-1-one (932-28-5)

Guidance literature:

With hydrogenchloride; In diethyl ether; at -20 ℃; for 3h; Yield given;

DOI:10.1016/S0968-0896(97)00083-7

upstream raw materials:

diazomethane

Cyclopentanecarboxylic acid chloride

1-Cyclopentyl-2-diazo-1-ethanone

cyclopentanecarboxylic acid

Downstream raw materials:

methyl 1-methylcyclopentanecarboxylate

1-methylcyclopentanecarboxylic acid

1-cyclopentyl-1-methoxy-oxirane

2-[4-(2-Cyclopentyl-2-oxo-ethoxy)-2-fluoro-phenyl]-2-methyl-propionitrile