(S)-(4-chloropyridin-3-yl)(2-(hydroxydiphenylmethyl)pyrrolidin-1-yl)methanone

Base Information

Chemical Name:(S)-(4-chloropyridin-3-yl)(2-(hydroxydiphenylmethyl)pyrrolidin-1-yl)methanone
CAS No.:851010-71-4
Molecular Formula:C₂₃H₂₁ClN₂O₂
Molecular Weight:392.885
Hs Code.:

Synonyms:(S)-(4-chloropyridin-3-yl)(2-(hydroxydiphenylmethyl)pyrrolidin-1-yl)methanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-(4-chloropyridin-3-yl)(2-(hydroxydiphenylmethyl)pyrrolidin-1-yl)methanone

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Technology Process of (S)-(4-chloropyridin-3-yl)(2-(hydroxydiphenylmethyl)pyrrolidin-1-yl)methanone

There total 3 articles about (S)-(4-chloropyridin-3-yl)(2-(hydroxydiphenylmethyl)pyrrolidin-1-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 100791-00-2
4-chloronicotinoyl chloride

: 22348-32-9,63401-04-7,112022-88-5,112068-01-6
(S)-diphenylprolinol

: 851010-71-4
(S)-(4-chloropyridin-3-yl)(2-(hydroxydiphenylmethyl)pyrrolidin-1-yl)methanone

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 16.16h; Inert atmosphere;
DOI:10.1055/s-0033-1339286

Reference yield:

: 22348-32-9,63401-04-7,112022-88-5,112068-01-6
(S)-diphenylprolinol

: 10177-29-4
4-chloronicotinic acid

: 851010-71-4
(S)-(4-chloropyridin-3-yl)(2-(hydroxydiphenylmethyl)pyrrolidin-1-yl)methanone

Guidance literature:: 4-chloronicotinic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 0 - 20 ℃; for 2h;

(S)-diphenylprolinol; With triethylamine; In dichloromethane; at 0 - 20 ℃; for 8h;
DOI:10.1002/adsc.201700849

Reference yield:

: 10177-29-4
4-chloronicotinic acid

: 851010-71-4
(S)-(4-chloropyridin-3-yl)(2-(hydroxydiphenylmethyl)pyrrolidin-1-yl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1: SOCl₂ / 2 h / 80 °C

2: Et₃N / 12 h / 0 - 20 °C

With thionyl chloride; triethylamine;
DOI:10.1039/b419335k