3-[1-(4-carbamoyl-2-methylphenyl)-5-(5-imidazole-1-ylthiophene-2-yl)-1H-pyrrole-2-yl]propionic acid ethyl ester

Base Information

Chemical Name:3-[1-(4-carbamoyl-2-methylphenyl)-5-(5-imidazole-1-ylthiophene-2-yl)-1H-pyrrole-2-yl]propionic acid ethyl ester
CAS No.:1208316-10-2
Molecular Formula:C₂₄H₂₄N₄O₃S
Molecular Weight:448.546
Hs Code.:

Synonyms:3-[1-(4-carbamoyl-2-methylphenyl)-5-(5-imidazole-1-ylthiophene-2-yl)-1H-pyrrole-2-yl]propionic acid ethyl ester

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Chemical Property of 3-[1-(4-carbamoyl-2-methylphenyl)-5-(5-imidazole-1-ylthiophene-2-yl)-1H-pyrrole-2-yl]propionic acid ethyl ester

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Technology Process of 3-[1-(4-carbamoyl-2-methylphenyl)-5-(5-imidazole-1-ylthiophene-2-yl)-1H-pyrrole-2-yl]propionic acid ethyl ester

There total 6 articles about 3-[1-(4-carbamoyl-2-methylphenyl)-5-(5-imidazole-1-ylthiophene-2-yl)-1H-pyrrole-2-yl]propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 288-32-4
1H-imidazole

: 1208318-19-7
C₂₁H₂₁BrN₂O₃S

: 1208316-10-2
3-[1-(4-carbamoyl-2-methylphenyl)-5-(5-imidazole-1-ylthiophene-2-yl)-1H-pyrrole-2-yl]propionic acid ethyl ester

Guidance literature:: With copper(l) iodide; potassium carbonate; L-proline; In dimethyl sulfoxide; at 120 ℃; for 0.5h; Microwave irradiation;
DOI:10.1016/j.bmcl.2011.07.103

Reference yield:

: 5370-25-2
2-Acetyl-5-bromothiophene

: 1208316-10-2
3-[1-(4-carbamoyl-2-methylphenyl)-5-(5-imidazole-1-ylthiophene-2-yl)-1H-pyrrole-2-yl]propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydroxide / ethanol; water / 20 °C

2: hydrogen bromide / water / 36 h / Reflux

3: toluene-4-sulfonic acid / ethanol / Reflux

4: copper(l) iodide; potassium carbonate; L-proline / dimethyl sulfoxide / 0.5 h / 120 °C / Microwave irradiation

With copper(l) iodide; hydrogen bromide; potassium carbonate; toluene-4-sulfonic acid; L-proline; sodium hydroxide; In ethanol; water; dimethyl sulfoxide;
DOI:10.1016/j.bmcl.2011.07.103

Reference yield:

: 98-01-1
furfural

: 1208316-10-2
3-[1-(4-carbamoyl-2-methylphenyl)-5-(5-imidazole-1-ylthiophene-2-yl)-1H-pyrrole-2-yl]propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydroxide / ethanol; water / 20 °C

2: hydrogen bromide / water / 36 h / Reflux

3: toluene-4-sulfonic acid / ethanol / Reflux

4: copper(l) iodide; potassium carbonate; L-proline / dimethyl sulfoxide / 0.5 h / 120 °C / Microwave irradiation

With copper(l) iodide; hydrogen bromide; potassium carbonate; toluene-4-sulfonic acid; L-proline; sodium hydroxide; In ethanol; water; dimethyl sulfoxide;
DOI:10.1016/j.bmcl.2011.07.103