9-benzyl-6-chloro-7,8-dihydro-2-iodo-7-propargylpurine

Base Information

• Chemical Name: 9-benzyl-6-chloro-7,8-dihydro-2-iodo-7-propargylpurine
• CAS No.: 1258274-86-0
• Molecular Formula: C₁₅H₁₂ClIN₄
• Molecular Weight: 410.645
• Mol file: 1258274-86-0.mol

Synonyms:9-benzyl-6-chloro-7,8-dihydro-2-iodo-7-propargylpurine

Chemical Property of 9-benzyl-6-chloro-7,8-dihydro-2-iodo-7-propargylpurine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 9-benzyl-6-chloro-7,8-dihydro-2-iodo-7-propargylpurine

There total 2 articles about 9-benzyl-6-chloro-7,8-dihydro-2-iodo-7-propargylpurine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

6-chloro-9-benzyl-7,8-dihydro-2-iodopurine (1258274-73-5) + propargyl bromide (106-96-7) → 9-benzyl-6-chloro-7,8-dihydro-2-iodo-7-propargylpurine (1258274-86-0)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1021/ol1025525

Reference yield:

9-benzyl-6-chloro-2-iodo-9H-purine (176515-41-6) → 9-benzyl-6-chloro-7,8-dihydro-2-iodo-7-propargylpurine (1258274-86-0)

Guidance literature:

Multi-step reaction with 2 steps

1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 2 h / 20 °C / Inert atmosphere

2: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / 20 °C / Inert atmosphere

With sodium hydride; diisobutylaluminium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; toluene; mineral oil;

DOI:10.1021/ol1025525

upstream raw materials:

6-chloro-9-benzyl-7,8-dihydro-2-iodopurine

propargyl bromide

9-benzyl-6-chloro-2-iodo-9H-purine