(1'R,2'R,3'S)-1-[2'-benzoyloxymethyl-3'-(hydroxymethyl)cyclobutyl]-N⁴-benzoylcytosine

Base Information

• Chemical Name: (1'R,2'R,3'S)-1-[2'-benzoyloxymethyl-3'-(hydroxymethyl)cyclobutyl]-N⁴-benzoylcytosine
• CAS No.: 283598-04-9
• Molecular Formula: C₂₄H₂₃N₃O₅
• Molecular Weight: 433.464

Synonyms:(1'R,2'R,3'S)-1-[2'-benzoyloxymethyl-3'-(hydroxymethyl)cyclobutyl]-N⁴-benzoylcytosine

Chemical Property of (1'R,2'R,3'S)-1-[2'-benzoyloxymethyl-3'-(hydroxymethyl)cyclobutyl]-N⁴-benzoylcytosine

Chemical Property:

Purity/Quality:

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Technology Process of (1'R,2'R,3'S)-1-[2'-benzoyloxymethyl-3'-(hydroxymethyl)cyclobutyl]-N⁴-benzoylcytosine

There total 3 articles about (1'R,2'R,3'S)-1-[2'-benzoyloxymethyl-3'-(hydroxymethyl)cyclobutyl]-N⁴-benzoylcytosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

(1'R,2'R,3'S)-1-[2',3'-bis(benzoyloxymethyl)cyclobutyl]-N4-benzoylcytosine (283597-98-8) → (1'R,2'R,3'S)-1-[2'-benzoyloxymethyl-3'-(hydroxymethyl)cyclobutyl]-N4-benzoylcytosine (283598-04-9)

Guidance literature:

With Lipase MY; In phosphate buffer; acetone; at 36 ℃; for 360h; pH=7.0; Enzymatic reaction;

DOI:10.1016/S0040-4020(00)00162-9

Reference yield:

<1S-(1α,2β,3β)>-3-<<(4-methylphenyl)sulfonyl>oxy>-1,2-cyclobutanedimethanol dibenzoate ester (132294-18-9) → (1'R,2'R,3'S)-1-[2'-benzoyloxymethyl-3'-(hydroxymethyl)cyclobutyl]-N4-benzoylcytosine (283598-04-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 36 percent

2: 71 percent / lipase MY / acetone; aq. phosphate buffer / 360 h / 36 °C / pH 7.0 / Enzymatic reaction

With Lipase MY; In phosphate buffer; acetone; 2: Hydrolysis;

DOI:10.1016/S0040-4020(00)00162-9

Reference yield:

benzyl chloride (100-44-7) → (1'R,2'R,3'S)-1-[2'-benzoyloxymethyl-3'-(hydroxymethyl)cyclobutyl]-N4-benzoylcytosine (283598-04-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 36 percent

2: 71 percent / lipase MY / acetone; aq. phosphate buffer / 360 h / 36 °C / pH 7.0 / Enzymatic reaction

With Lipase MY; In phosphate buffer; acetone; 2: Hydrolysis;

DOI:10.1016/S0040-4020(00)00162-9

upstream raw materials:

(1'R,2'R,3'S)-1-[2',3'-bis(benzoyloxymethyl)cyclobutyl]-N⁴-benzoylcytosine

<1S-(1α,2β,3β)>-3-<<(4-methylphenyl)sulfonyl>oxy>-1,2-cyclobutanedimethanol dibenzoate ester

benzyl chloride

Downstream raw materials:

(1'R,2'R,3'S)-1-{2'-hydroxymethyl-3'-[bis(p-methoxyphenyl)phenylmethyloxymethyl]cyclobutyl}-N⁴-benzoylcytosine

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