methyl ester of 4-phenyl-2-(p-tolylamino)-4-oxo-2-butenoic acid

Base Information

• Chemical Name: methyl ester of 4-phenyl-2-(p-tolylamino)-4-oxo-2-butenoic acid
• CAS No.: 126324-65-0
• Molecular Formula: C₁₈H₁₇NO₃
• Molecular Weight: 295.338
• Mol file: 126324-65-0.mol

Synonyms:methyl ester of 4-phenyl-2-(p-tolylamino)-4-oxo-2-butenoic acid

Chemical Property of methyl ester of 4-phenyl-2-(p-tolylamino)-4-oxo-2-butenoic acid

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of methyl ester of 4-phenyl-2-(p-tolylamino)-4-oxo-2-butenoic acid

There total 2 articles about methyl ester of 4-phenyl-2-(p-tolylamino)-4-oxo-2-butenoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.0%

methyl 3-benzoyl-1-(4-methoxyphenyl)-4,5-dioxo-4,5-dihydro-1H-pyrrole-2-carboxylate (113416-39-0) + p-toluidine (106-49-0,12221-03-3) → N-(p-methoxyphenyl)-N'-(p-tolyl)-oxalamide (22505-25-5) + methyl ester of 4-phenyl-2-(p-tolylamino)-4-oxo-2-butenoic acid (126324-65-0)

Guidance literature:

In benzene; for 1h; Heating;

Reference yield:

(Z)-methyl 2-hydroxy-4-oxo-4-phenylbut-2-enoate (39847-99-9) + p-toluidine (106-49-0,12221-03-3) → methyl ester of 4-phenyl-2-(p-tolylamino)-4-oxo-2-butenoic acid (126324-65-0)

Guidance literature:

With acetic acid; In ethanol; at 25 ℃; Rate constant; Mechanism; pH 5.45; other pH values;

Reference yield: 81.0%

methyl ester of 4-phenyl-2-(p-tolylamino)-4-oxo-2-butenoic acid (126324-65-0) + methyl 3-benzoyl-1-(4-methylphenyl)-4,5-dioxo-4,5-dihydro-1H-pyrrole-2-carboxylate (113416-36-7) → methyl 4,9-dibenzoyl-3-hydroxy-1,7-bis(4-methylphenyl)-2,6-dioxo-1,7-diazaspiro[4.4]nona-3,8-diene-8-carboxylate

Guidance literature:

In toluene; for 5h; Reflux;

DOI:10.1134/S1070428016050158

upstream raw materials:

(Z)-methyl 2-hydroxy-4-oxo-4-phenylbut-2-enoate

p-toluidine

methyl 3-benzoyl-1-(4-methoxyphenyl)-4,5-dioxo-4,5-dihydro-1H-pyrrole-2-carboxylate

Downstream raw materials:

N-p-Tolylbenzoylpyruvamid