tert-butyl 3-(6-(dibenzylamino)-5-nitropyrimidin-4-ylamino)phenylcarbamate

Base Information

• Chemical Name: tert-butyl 3-(6-(dibenzylamino)-5-nitropyrimidin-4-ylamino)phenylcarbamate
• CAS No.: 1448444-47-0
• Molecular Formula: C₂₉H₃₀N₆O₄
• Molecular Weight: 526.595

Synonyms:tert-butyl 3-(6-(dibenzylamino)-5-nitropyrimidin-4-ylamino)phenylcarbamate

Chemical Property of tert-butyl 3-(6-(dibenzylamino)-5-nitropyrimidin-4-ylamino)phenylcarbamate

Chemical Property:

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Technology Process of tert-butyl 3-(6-(dibenzylamino)-5-nitropyrimidin-4-ylamino)phenylcarbamate

There total 2 articles about tert-butyl 3-(6-(dibenzylamino)-5-nitropyrimidin-4-ylamino)phenylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

(3-aminophenyl)carbamic acid tert-butyl ester (68621-88-5) + N,N-dibenzyl-6-chloro-5-nitropyrimidine-4-amine (882272-97-1) → tert-butyl 3-(6-(dibenzylamino)-5-nitropyrimidin-4-ylamino)phenylcarbamate (1448444-47-0)

Guidance literature:

With triethylamine; In 1,4-dioxane; water; at 70 ℃; for 6h; Inert atmosphere;

Reference yield:

dibenzylamine (103-49-1) → tert-butyl 3-(6-(dibenzylamino)-5-nitropyrimidin-4-ylamino)phenylcarbamate (1448444-47-0)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 2.5 h / 0 °C / Inert atmosphere

2: triethylamine / 1,4-dioxane; water / 6 h / 70 °C / Inert atmosphere

With triethylamine; In 1,4-dioxane; dichloromethane; water;

Reference yield: 46.1%

tert-butyl 3-(6-(dibenzylamino)-5-nitropyrimidin-4-ylamino)phenylcarbamate (1448444-47-0) → tert-butyl 3-(5-amino-6-(dibenzylamino)pyrimidin-4-ylamino)phenylcarbamate (1448444-48-1)

Guidance literature:

With iron; ammonium chloride; In tetrahydrofuran; methanol; water; at 50 ℃; for 7h; Inert atmosphere;

upstream raw materials:

(3-aminophenyl)carbamic acid tert-butyl ester

N,N-dibenzyl-6-chloro-5-nitropyrimidine-4-amine

dibenzylamine

Downstream raw materials:

tert-butyl 3-(5-amino-6-(dibenzylamino)pyrimidin-4-ylamino)phenylcarbamate

(E)-N-(3-(6-amino-8-oxo-7-(4-phenoxyphenyl)-7H-purin-9(8H)-yl)phenyl)-4-(dimethylamino)but-2-enamide

tert-butyl 3-(6-amino-7-(4-chlorophenyl)-8-oxo-7H-purin-9(8H)-yl)phenylcarbamate

6-amino-9-(3-aminophenyl)-7-(4-chlorophenyl)-7H-purin-8(9H)-one

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