2-(3-biphenyl-4-yl-2-{hydroxy-[(1-isobutyryloxy-ethoxycarbonylamino)thiophen-3-yl-methyl]phosphinoylmethyl}propionylamino)propionic acid

Base Information

Chemical Name:2-(3-biphenyl-4-yl-2-{hydroxy-[(1-isobutyryloxy-ethoxycarbonylamino)thiophen-3-yl-methyl]phosphinoylmethyl}propionylamino)propionic acid
CAS No.:1206514-61-5
Molecular Formula:C₃₁H₃₇N₂O₉PS
Molecular Weight:644.683
Hs Code.:

2-(3-biphenyl-4-yl-2-{hydroxy-[(1-isobutyryloxy-ethoxycarbonylamino)thiophen-3-yl-methyl]phosphinoylmethyl}propionylamino)propionic acid

Synonyms:2-(3-biphenyl-4-yl-2-{hydroxy-[(1-isobutyryloxy-ethoxycarbonylamino)thiophen-3-yl-methyl]phosphinoylmethyl}propionylamino)propionic acid

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Chemical Property of 2-(3-biphenyl-4-yl-2-{hydroxy-[(1-isobutyryloxy-ethoxycarbonylamino)thiophen-3-yl-methyl]phosphinoylmethyl}propionylamino)propionic acid

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Technology Process of 2-(3-biphenyl-4-yl-2-{hydroxy-[(1-isobutyryloxy-ethoxycarbonylamino)thiophen-3-yl-methyl]phosphinoylmethyl}propionylamino)propionic acid

There total 3 articles about 2-(3-biphenyl-4-yl-2-{hydroxy-[(1-isobutyryloxy-ethoxycarbonylamino)thiophen-3-yl-methyl]phosphinoylmethyl}propionylamino)propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 860035-10-5
1-[[[(2,5-dioxopyrrolidin-1-yl)oxy]carbonyl]oxy]ethyl 2-methylpropanoate

: (2S)-2-((2S)-3-(((R)-amino(thiophen-3-yl)methyl)(hydroxy)phosphoryl)-2-(biphenyl-4-ylmethyl)propanamido)propanoic acid trifluoroacetate

: 1206514-61-5
2-(3-biphenyl-4-yl-2-{hydroxy-[(1-isobutyryloxy-ethoxycarbonylamino)thiophen-3-yl-methyl]phosphinoylmethyl}propionylamino)propionic acid

Guidance literature:: With sodium hydrogencarbonate; In acetonitrile; at 60 ℃; for 1h;

Reference yield:

: (R)-(benzyloxycarbonylamino)(thiophen-3-yl)methyl-(2-(biphenyl-4-ylmethyl)-3-((S)-1-methoxy-1-oxopropan-2-ylamino)-3-oxopropyl)phosphinic acid

: 1206514-61-5
2-(3-biphenyl-4-yl-2-{hydroxy-[(1-isobutyryloxy-ethoxycarbonylamino)thiophen-3-yl-methyl]phosphinoylmethyl}propionylamino)propionic acid

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / acetone / 2.5 h / 20 °C

2: hydrogen bromide; acetic acid / 2 h / 20 °C

3: sodium hydrogencarbonate / acetonitrile / 1 h / 60 °C

With hydrogen bromide; sodium hydrogencarbonate; acetic acid; sodium hydroxide; In acetone; acetonitrile;

Reference yield:

: 2-{2-[(benzyloxycarbonylamino-thiophen-3-yl-methyl)hydroxy-phosphinoylmethyl]-3-biphenyl-4-yl-propionylamino}propionic acid

: 1206514-61-5
2-(3-biphenyl-4-yl-2-{hydroxy-[(1-isobutyryloxy-ethoxycarbonylamino)thiophen-3-yl-methyl]phosphinoylmethyl}propionylamino)propionic acid

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen bromide; acetic acid / 2 h / 20 °C

2: sodium hydrogencarbonate / acetonitrile / 1 h / 60 °C

With hydrogen bromide; sodium hydrogencarbonate; acetic acid; In acetonitrile;