Technology Process of N-(tert-butoxycarbonyl)alanylalanyl-N-(4-nitrophenyl)alaninamide
There total 5 articles about N-(tert-butoxycarbonyl)alanylalanyl-N-(4-nitrophenyl)alaninamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide;
In
N,N-dimethyl-formamide;
Ambient temperature;
DOI:10.1248/cpb.33.5301
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) PCl3, pyridine / 2.) pyridine, 70-80 degC, 3 h, room temperature, 10 h
2: 25percent HBr, acetic acid
3: 58 percent / 1-hydroxybenzotriazole, Et3N, N,N'-dicyclohexylcarbodiimide / dimethylformamide / Ambient temperature
4: 5.4N HCl / dioxane
5: 53 percent / 1-hydroxybenzotriazole, Et3N, N,N'-dicyclohexylcarbodiimide / dimethylformamide / Ambient temperature
With
pyridine; hydrogenchloride; hydrogen bromide; benzotriazol-1-ol; acetic acid; triethylamine; dicyclohexyl-carbodiimide; phosphorus trichloride;
In
1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.33.5301
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 5.4N HCl / dioxane
2: 53 percent / 1-hydroxybenzotriazole, Et3N, N,N'-dicyclohexylcarbodiimide / dimethylformamide / Ambient temperature
With
hydrogenchloride; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide;
In
1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.33.5301
