5-amino-6-chloro-4-(2-hydroxy-1-propyl)amino-2-phenylpyrimidine

Base Information

• Chemical Name: 5-amino-6-chloro-4-(2-hydroxy-1-propyl)amino-2-phenylpyrimidine
• CAS No.: 639070-96-5
• Molecular Formula: C₁₃H₁₅ClN₄O
• Molecular Weight: 278.741
• Mol file: 639070-96-5.mol

Synonyms:5-amino-6-chloro-4-(2-hydroxy-1-propyl)amino-2-phenylpyrimidine

Chemical Property of 5-amino-6-chloro-4-(2-hydroxy-1-propyl)amino-2-phenylpyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 5-amino-6-chloro-4-(2-hydroxy-1-propyl)amino-2-phenylpyrimidine

There total 1 articles about 5-amino-6-chloro-4-(2-hydroxy-1-propyl)amino-2-phenylpyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

3-amino-2-propanol (78-96-6,1674-56-2) + 5-amino-4,6-dichloro-2-phenylpyrimidine (20959-02-8) → 5-amino-6-chloro-4-(2-hydroxy-1-propyl)amino-2-phenylpyrimidine (639070-96-5)

Guidance literature:

With N,N-diethylaniline; In ethanol; at 110 ℃; for 12h;

DOI:10.1016/S0223-5234(03)00147-8

Reference yield:

5-amino-6-chloro-4-(2-hydroxy-1-propyl)amino-2-phenylpyrimidine (639070-96-5) → 6-chloro-9-(2-hydroxy-1-propyl)-2-phenyl-8-azapurine (1027375-81-0)

Guidance literature:

With acetic acid; sodium nitrite; In tetrahydrofuran; water; at 0 - 20 ℃; for 5h;

DOI:10.1016/S0223-5234(03)00147-8

Reference yield:

5-amino-6-chloro-4-(2-hydroxy-1-propyl)amino-2-phenylpyrimidine (639070-96-5) → 1-(6-amino-2-phenyl-purin-9-yl)-propan-2-ol

Guidance literature:

Multi-step reaction with 2 steps

1: HCl / 12 h / 20 °C

2: NH₃ / ethanol / 24 h / 120 °C

With hydrogenchloride; ammonia; In ethanol;

DOI:10.1016/S0223-5234(03)00147-8

upstream raw materials:

3-amino-2-propanol

5-amino-4,6-dichloro-2-phenylpyrimidine

Downstream raw materials:

6-chloro-9-(2-hydroxy-1-propyl)-2-phenylpurine

6-chloro-9-(2-hydroxy-1-propyl)-2-phenyl-8-azapurine