(2R,3S,5R)-5-(1H-benzo[d]imidazol-1-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)tetrahydrofuran-3-ol

Base Information

Chemical Name:(2R,3S,5R)-5-(1H-benzo[d]imidazol-1-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)tetrahydrofuran-3-ol
CAS No.:259881-62-4
Molecular Formula:C₃₃H₃₂N₂O₅
Molecular Weight:536.627
Hs Code.:

Synonyms:(2R,3S,5R)-5-(1H-benzo[d]imidazol-1-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)tetrahydrofuran-3-ol

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Chemical Property of (2R,3S,5R)-5-(1H-benzo[d]imidazol-1-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)tetrahydrofuran-3-ol

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Technology Process of (2R,3S,5R)-5-(1H-benzo[d]imidazol-1-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)tetrahydrofuran-3-ol

There total 7 articles about (2R,3S,5R)-5-(1H-benzo[d]imidazol-1-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)tetrahydrofuran-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: (2R,3S,5R)-5-(1H-benzo[d]imidazol-1-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol

: 259881-62-4
(2R,3S,5R)-5-(1H-benzo[d]imidazol-1-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)tetrahydrofuran-3-ol

Guidance literature:: With pyridine; at 20 ℃;
DOI:10.1080/07328319908044634

Reference yield:

: 728-01-8
1-(β-D-ribofuranosyl)benzimidazole

: 259881-62-4
(2R,3S,5R)-5-(1H-benzo[d]imidazol-1-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)tetrahydrofuran-3-ol

Guidance literature:: Multi-step reaction with 5 steps

1: 62 percent / pyridine / Ambient temperature

2: 4-(dimethylamino)pyridine / acetonitrile / 2 h / Ambient temperature

3: 85 percent / Bu₃SnH, 2,2'-azobis(2-methyl-propanenitrile) / toluene / 2 h / Heating

4: 80 percent / Bu₄NF / tetrahydrofuran / 0.25 h

5: pyridine / 1.) 2 h, 2.) MeOH, 30 min

With pyridine; dmap; 2,2'-azobis(isobutyronitrile); tetrabutyl ammonium fluoride; tri-n-butyl-tin hydride; In tetrahydrofuran; pyridine; toluene; acetonitrile;
DOI:10.1002/hlca.19870700117

Reference yield:

: 109292-65-1
1-<2'-deoxy-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranosyl>-1H-benzimidazole

: 259881-62-4
(2R,3S,5R)-5-(1H-benzo[d]imidazol-1-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)tetrahydrofuran-3-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / Bu₄NF / tetrahydrofuran / 0.25 h

2: pyridine / 1.) 2 h, 2.) MeOH, 30 min

With pyridine; tetrabutyl ammonium fluoride; In tetrahydrofuran;
DOI:10.1002/hlca.19870700117