5-[(3R,5S)-1-benzyl-3-hydroxy-2-oxo-5-pyrrolidinyl]-1,2:3,4-di-O-isopropylidene-α-D-galacto-pentopyranose

Base Information

• Chemical Name: 5-[(3R,5S)-1-benzyl-3-hydroxy-2-oxo-5-pyrrolidinyl]-1,2:3,4-di-O-isopropylidene-α-D-galacto-pentopyranose
• CAS No.: 649571-93-7
• Molecular Formula: C₂₂H₂₉NO₇
• Molecular Weight: 419.475
• Mol file: 649571-93-7.mol

Synonyms:5-[(3R,5S)-1-benzyl-3-hydroxy-2-oxo-5-pyrrolidinyl]-1,2:3,4-di-O-isopropylidene-α-D-galacto-pentopyranose

Chemical Property of 5-[(3R,5S)-1-benzyl-3-hydroxy-2-oxo-5-pyrrolidinyl]-1,2:3,4-di-O-isopropylidene-α-D-galacto-pentopyranose

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-[(3R,5S)-1-benzyl-3-hydroxy-2-oxo-5-pyrrolidinyl]-1,2:3,4-di-O-isopropylidene-α-D-galacto-pentopyranose

There total 1 articles about 5-[(3R,5S)-1-benzyl-3-hydroxy-2-oxo-5-pyrrolidinyl]-1,2:3,4-di-O-isopropylidene-α-D-galacto-pentopyranose which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

4-[(3S,5R)-2-benzyl-5-(methoxycarbonyl)-3-isoxazolidinyl]-1,2:3,4-di-O-isopropylidene-α-D-galacto-pentopyranose (649571-87-9) → 5-[(3R,5S)-1-benzyl-3-hydroxy-2-oxo-5-pyrrolidinyl]-1,2:3,4-di-O-isopropylidene-α-D-galacto-pentopyranose (649571-93-7)

Guidance literature:

With water; acetic acid; zinc; In tetrahydrofuran; at 60 ℃; for 5h;

DOI:10.1016/j.tetasy.2003.08.027

Reference yield: 95.0%

(R)-methoxytrifluoromethylphenylacetyl chloride (20445-33-4,39637-99-5) + 5-[(3R,5S)-1-benzyl-3-hydroxy-2-oxo-5-pyrrolidinyl]-1,2:3,4-di-O-isopropylidene-α-D-galacto-pentopyranose (649571-93-7) → 5-[(3R,5S)-1-benzyl-3-[(1S)-1-methoxy-1-phenyl-1-(trifluoromethyl)acetoxy]-2-oxo-5-pyrrolidinyl]-1,2:3,4-di-O-isopropylidene-α-D-galacto-pentopyranose

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 12h;

DOI:10.1016/j.tetasy.2003.08.027

Reference yield: 93.0%

(S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride (39637-99-5,20445-33-4) + 5-[(3R,5S)-1-benzyl-3-hydroxy-2-oxo-5-pyrrolidinyl]-1,2:3,4-di-O-isopropylidene-α-D-galacto-pentopyranose (649571-93-7) → 5-[(3R,5S)-1-benzyl-3-[(1R)-1-methoxy-1-phenyl-1-(trifluoromethyl)acetoxy]-2-oxo-5-pyrrolidinyl]-1,2:3,4-di-O-isopropylidene-α-D-galacto-pentopyranose

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 12h;

DOI:10.1016/j.tetasy.2003.08.027

upstream raw materials:

4-[(3S,5R)-2-benzyl-5-(methoxycarbonyl)-3-isoxazolidinyl]-1,2:3,4-di-O-isopropylidene-α-D-galacto-pentopyranose