(S)-5-acetyl-4-(3-methoxyphenyl)-3,4-dihydropyrano[3,2-b]indol-2(5H)-one

Base Information

Chemical Name:(S)-5-acetyl-4-(3-methoxyphenyl)-3,4-dihydropyrano[3,2-b]indol-2(5H)-one
CAS No.:1629135-31-4
Molecular Formula:C₂₀H₁₇NO₄
Molecular Weight:335.359
Hs Code.:

Synonyms:(S)-5-acetyl-4-(3-methoxyphenyl)-3,4-dihydropyrano[3,2-b]indol-2(5H)-one

Suppliers and Price of (S)-5-acetyl-4-(3-methoxyphenyl)-3,4-dihydropyrano[3,2-b]indol-2(5H)-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-5-acetyl-4-(3-methoxyphenyl)-3,4-dihydropyrano[3,2-b]indol-2(5H)-one

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Technology Process of (S)-5-acetyl-4-(3-methoxyphenyl)-3,4-dihydropyrano[3,2-b]indol-2(5H)-one

There total 3 articles about (S)-5-acetyl-4-(3-methoxyphenyl)-3,4-dihydropyrano[3,2-b]indol-2(5H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 16800-67-2
N,O-diacetylindoxyl

: 134057-98-0
2-bromo-3-(3-methoxyphenyl)-2-propenal

: 1629135-31-4
(S)-5-acetyl-4-(3-methoxyphenyl)-3,4-dihydropyrano[3,2-b]indol-2(5H)-one

Guidance literature:: With N,N,N,N,-tetramethylethylenediamine; BF₄^(1-)*C₂₁H₂₂N₃O⁽¹⁺⁾; In 1,3,5-trimethyl-benzene; at 20 ℃; enantioselective reaction; Inert atmosphere; Schlenk technique;
DOI:10.1002/asia.201402052

Reference yield:

: 612-42-0
phenylglycine-o-carboxylic acid

: 1629135-31-4
(S)-5-acetyl-4-(3-methoxyphenyl)-3,4-dihydropyrano[3,2-b]indol-2(5H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: sodium acetate / Reflux

2: BF₄^(1-)*C₂₁H₂₂N₃O⁽¹⁺⁾; N,N,N,N,-tetramethylethylenediamine / 1,3,5-trimethyl-benzene / 20 °C / Inert atmosphere; Schlenk technique

With N,N,N,N,-tetramethylethylenediamine; BF₄^(1-)*C₂₁H₂₂N₃O⁽¹⁺⁾; sodium acetate; In 1,3,5-trimethyl-benzene;
DOI:10.1002/asia.201402052

Reference yield:

: 118-91-2
ortho-chlorobenzoic acid

: 1629135-31-4
(S)-5-acetyl-4-(3-methoxyphenyl)-3,4-dihydropyrano[3,2-b]indol-2(5H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: copper; potassium carbonate / N,N-dimethyl-formamide / Reflux

2: sodium acetate / Reflux

3: BF₄^(1-)*C₂₁H₂₂N₃O⁽¹⁺⁾; N,N,N,N,-tetramethylethylenediamine / 1,3,5-trimethyl-benzene / 20 °C / Inert atmosphere; Schlenk technique

With N,N,N,N,-tetramethylethylenediamine; BF₄^(1-)*C₂₁H₂₂N₃O⁽¹⁺⁾; sodium acetate; copper; potassium carbonate; In N,N-dimethyl-formamide; 1,3,5-trimethyl-benzene;
DOI:10.1002/asia.201402052