[(R)-1-((4S,5S)-5-Benzyloxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-prop-2-ynyl]-carbamic acid tert-butyl ester

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Chemical Name:[(R)-1-((4S,5S)-5-Benzyloxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-prop-2-ynyl]-carbamic acid tert-butyl ester
CAS No.:90661-50-0
Molecular Formula:C₂₁H₂₉NO₅
Molecular Weight:375.465
Hs Code.:

Synonyms:[(R)-1-((4S,5S)-5-Benzyloxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-prop-2-ynyl]-carbamic acid tert-butyl ester

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Chemical Property of [(R)-1-((4S,5S)-5-Benzyloxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-prop-2-ynyl]-carbamic acid tert-butyl ester

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Technology Process of [(R)-1-((4S,5S)-5-Benzyloxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-prop-2-ynyl]-carbamic acid tert-butyl ester

There total 10 articles about [(R)-1-((4S,5S)-5-Benzyloxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-prop-2-ynyl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: (R)-1-((4S,5S)-5-Benzyloxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-prop-2-ynylamine

: 41840-28-2
S-tert-butoxycarbonyl-4,6-dimethyl-2-mercaptopyrimidine

: 90661-50-0
[(R)-1-((4S,5S)-5-Benzyloxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-prop-2-ynyl]-carbamic acid tert-butyl ester

Guidance literature:: With triethylamine; In 1,4-dioxane; water; Ambient temperature;
DOI:10.1246/cl.1984.405

Reference yield:

: 81028-12-8
(4S,5R)-4-benzyloxymethyl-2,2-dimethyl-1,3-dioxolane-5-carboxaldehyde

: 90661-50-0
[(R)-1-((4S,5S)-5-Benzyloxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-prop-2-ynyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 83 percent / TiCl₄-Ti(O-i-Pr)4

2: 84 percent / pyridine / 0 °C

3: 85 percent / LiN₃ / hexamethylphosphoric acid triamide / 0 °C

4: NH₄F / n-Bu₄N(+)*HSO₄(-) / Ambient temperature

5: LiAlH₄ / diethyl ether / 0 °C

6: 76 percent / Et₃N / H₂O; dioxane / Ambient temperature

With ammonium fluoride; lithium aluminium tetrahydride; lithium azide; triethylamine; titanium(IV) isopropylate; tetra(n-butyl)ammonium hydrogensulfate; titanium tetrachloride; In 1,4-dioxane; pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; water;
DOI:10.1246/cl.1984.405

Reference yield:

: [(R)-3-Azido-3-((4S,5S)-5-benzyloxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-prop-1-ynyl]-trimethyl-silane

: 90661-50-0
[(R)-1-((4S,5S)-5-Benzyloxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-prop-2-ynyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: NH₄F / n-Bu₄N(+)*HSO₄(-) / Ambient temperature

2: LiAlH₄ / diethyl ether / 0 °C

3: 76 percent / Et₃N / H₂O; dioxane / Ambient temperature

With ammonium fluoride; lithium aluminium tetrahydride; triethylamine; tetra(n-butyl)ammonium hydrogensulfate; In 1,4-dioxane; diethyl ether; water;
DOI:10.1246/cl.1984.405