(3R,4S,5S)-5-Mwthyl-3,4-epimino-N-(4-methoxy-2,3,6-trimethylphenylsulfonyl)hept-1-ene

Base Information

Chemical Name:(3R,4S,5S)-5-Mwthyl-3,4-epimino-N-(4-methoxy-2,3,6-trimethylphenylsulfonyl)hept-1-ene
CAS No.:220307-12-0
Molecular Formula:C₁₈H₂₇NO₃S
Molecular Weight:337.483
Hs Code.:

Synonyms:(3R,4S,5S)-5-Mwthyl-3,4-epimino-N-(4-methoxy-2,3,6-trimethylphenylsulfonyl)hept-1-ene

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Chemical Property of (3R,4S,5S)-5-Mwthyl-3,4-epimino-N-(4-methoxy-2,3,6-trimethylphenylsulfonyl)hept-1-ene

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Technology Process of (3R,4S,5S)-5-Mwthyl-3,4-epimino-N-(4-methoxy-2,3,6-trimethylphenylsulfonyl)hept-1-ene

There total 9 articles about (3R,4S,5S)-5-Mwthyl-3,4-epimino-N-(4-methoxy-2,3,6-trimethylphenylsulfonyl)hept-1-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 220306-90-1
Carbonic acid (E)-(4S,5S)-4-(4-methoxy-2,3,6-trimethyl-benzenesulfonylamino)-5-methyl-hept-2-enyl ester methyl ester

: 220307-12-0
(3R,4S,5S)-5-Mwthyl-3,4-epimino-N-(4-methoxy-2,3,6-trimethylphenylsulfonyl)hept-1-ene

: (3S,4S,5S)-5-Mwthyl-3,4-epimino-N-(4-methoxy-2,3,6-trimethylphenylsulfonyl)hept-1-ene

Guidance literature:: tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; at 60 ℃; for 0.0833333h;
DOI:10.1039/a806882h

Reference yield: 75.0%

: 220652-44-8
(4S,5S,2Z)-O-Methoxycarbonyl-5-methyl-4-[(4-methoxy-2,3,6-trimethylphenylsulfonyl)amino]hept-2-en-1-ol

: 220307-12-0
(3R,4S,5S)-5-Mwthyl-3,4-epimino-N-(4-methoxy-2,3,6-trimethylphenylsulfonyl)hept-1-ene

: (3S,4S,5S)-5-Mwthyl-3,4-epimino-N-(4-methoxy-2,3,6-trimethylphenylsulfonyl)hept-1-ene

Guidance literature:: tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; at 65 ℃; for 0.0833333h;

Reference yield:

: 24629-25-2
(S)-isoleucinol

: 220307-12-0
(3R,4S,5S)-5-Mwthyl-3,4-epimino-N-(4-methoxy-2,3,6-trimethylphenylsulfonyl)hept-1-ene

Guidance literature:: Multi-step reaction with 6 steps

1: 80 percent / Et₃N / CHCl₃; dimethylformamide / 6 h / 0 °C

2: 1.) (COCl)2, DMSO, 2.) (i-Pr)2NEt / 1.) CHCl₃, hexane, -78 deg C, 30 min, 2.) -78 to 0 deg C, 30 min

3: CHCl₃ / 1 h / 0 - 20 °C

4: 88 percent / DIBAL / toluene; CHCl₃ / 1 h / -78 °C

5: 90 percent / Et₃N / tetrahydrofuran / 0.5 h / 0 °C

6: NaH / dimethylformamide / 0.5 h / 0 °C

With oxalyl dichloride; sodium hydride; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide; toluene;
DOI:10.1039/a806882h