(2R,(S)S)-2-[2-(p-tolylsulfinyl)phenyl]-2-(triisopropylsilyloxy)acetonitrile

Base Information

Chemical Name:(2R,(S)S)-2-[2-(p-tolylsulfinyl)phenyl]-2-(triisopropylsilyloxy)acetonitrile
CAS No.:861942-76-9
Molecular Formula:C₂₄H₃₃NO₂SSi
Molecular Weight:427.683
Hs Code.:

Synonyms:(2R,(S)S)-2-[2-(p-tolylsulfinyl)phenyl]-2-(triisopropylsilyloxy)acetonitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,(S)S)-2-[2-(p-tolylsulfinyl)phenyl]-2-(triisopropylsilyloxy)acetonitrile

Chemical Property:

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Technology Process of (2R,(S)S)-2-[2-(p-tolylsulfinyl)phenyl]-2-(triisopropylsilyloxy)acetonitrile

There total 1 articles about (2R,(S)S)-2-[2-(p-tolylsulfinyl)phenyl]-2-(triisopropylsilyloxy)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 861942-71-4
(S)‐2‐(p‐tolylsulfinyl)benzaldehyde

: 35856-38-3
(triisopropyl)silyl cyanide

: (2S,(S)S)-2-[2-(p-tolylsulfinyl)phenyl]-2-(triisopropylsilyloxy)acetonitrile

: 861942-76-9
(2R,(S)S)-2-[2-(p-tolylsulfinyl)phenyl]-2-(triisopropylsilyloxy)acetonitrile

Guidance literature:: With ytterbium(III) triflate; In dichloromethane; at 20 ℃; for 120h;
DOI:10.1016/j.tetasy.2005.04.031

Reference yield:

: 861942-76-9
(2R,(S)S)-2-[2-(p-tolylsulfinyl)phenyl]-2-(triisopropylsilyloxy)acetonitrile

: 861942-72-5
(2R,(S)S)-2-hydroxy-2-[2-(p-tolylsulfinyl)phenyl]acetonitrile

Guidance literature:: With tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran; at 20 ℃; for 16h;
DOI:10.1016/j.tetasy.2005.04.031

Reference yield:

: 861942-76-9
(2R,(S)S)-2-[2-(p-tolylsulfinyl)phenyl]-2-(triisopropylsilyloxy)acetonitrile

: 2-hydroxy-2-(2-p-tolylsulfanyl-phenyl)-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: AcOH; TBAF / tetrahydrofuran / 16 h / 20 °C

2.1: HBF₄ / CH₂Cl₂ / 4 h / 20 °C

2.2: NaI / CH₂Cl₂ / 15 h / 20 °C

With tetrafluoroboric acid; tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tetasy.2005.04.031