4-[(5-oxy-quinolinyl-8-amino)carbonyl-amino-(1-N-p-tolyl-3-t-butyl-pyrazol-5-yl)]-pyridin-5-N-methyl,6-imidazolone

Base Information

Chemical Name:4-[(5-oxy-quinolinyl-8-amino)carbonyl-amino-(1-N-p-tolyl-3-t-butyl-pyrazol-5-yl)]-pyridin-5-N-methyl,6-imidazolone
CAS No.:1192261-36-1
Molecular Formula:C₃₁H₃₀N₈O₃
Molecular Weight:562.631
Hs Code.:

Synonyms:4-[(5-oxy-quinolinyl-8-amino)carbonyl-amino-(1-N-p-tolyl-3-t-butyl-pyrazol-5-yl)]-pyridin-5-N-methyl,6-imidazolone

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Chemical Property of 4-[(5-oxy-quinolinyl-8-amino)carbonyl-amino-(1-N-p-tolyl-3-t-butyl-pyrazol-5-yl)]-pyridin-5-N-methyl,6-imidazolone

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Technology Process of 4-[(5-oxy-quinolinyl-8-amino)carbonyl-amino-(1-N-p-tolyl-3-t-butyl-pyrazol-5-yl)]-pyridin-5-N-methyl,6-imidazolone

There total 4 articles about 4-[(5-oxy-quinolinyl-8-amino)carbonyl-amino-(1-N-p-tolyl-3-t-butyl-pyrazol-5-yl)]-pyridin-5-N-methyl,6-imidazolone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1192261-68-9
4-(8-amino-quinolinyl-5-oxy)-pyridine-5-N-methyl-6-imidazolone

: 499972-03-1
3-(tert-butyl)-5-isocyanato-1-(p-tolyl)-1H-pyrazole

: 1192261-36-1
4-[(5-oxy-quinolinyl-8-amino)carbonyl-amino-(1-N-p-tolyl-3-t-butyl-pyrazol-5-yl)]-pyridin-5-N-methyl,6-imidazolone

Guidance literature:: In tetrahydrofuran; dichloromethane; at 40 ℃; for 18h;

Reference yield:

: 1192261-58-7
4-(8-N-BOC-amino-quinolinyl-5-oxy)-5-nitro-6-amino-pyridine

: 1192261-36-1
4-[(5-oxy-quinolinyl-8-amino)carbonyl-amino-(1-N-p-tolyl-3-t-butyl-pyrazol-5-yl)]-pyridin-5-N-methyl,6-imidazolone

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogen / palladium 10% on activated carbon / ethanol; ethyl acetate

2.1: pyridine / tetrahydrofuran / 0 - 20 °C

3.1: trifluoroacetic acid / 2.5 h / 20 °C

3.2: pH 7.5 - 8

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.67 h / 0 °C

4.2: 0 - 20 °C

5.1: sodium ethanolate / ethanol / 1 h / 100 °C / Microwave irradiation

6.1: tetrahydrofuran; dichloromethane / 18 h / 40 °C

With pyridine; hydrogen; sodium ethanolate; sodium hydride; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1192261-65-6
4-(8-N-BOC-amino-quinolinyl-5-oxy)-5-N-carbamoylethyl,6-amino-pyridine

: 1192261-36-1
4-[(5-oxy-quinolinyl-8-amino)carbonyl-amino-(1-N-p-tolyl-3-t-butyl-pyrazol-5-yl)]-pyridin-5-N-methyl,6-imidazolone

Guidance literature:: Multi-step reaction with 4 steps

1.1: trifluoroacetic acid / 2.5 h / 20 °C

1.2: pH 7.5 - 8

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.67 h / 0 °C

2.2: 0 - 20 °C

3.1: sodium ethanolate / ethanol / 1 h / 100 °C / Microwave irradiation

4.1: tetrahydrofuran; dichloromethane / 18 h / 40 °C

With sodium ethanolate; sodium hydride; trifluoroacetic acid; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;