6-CHLORO-2-(1,1-DIMETHYLETHYL)-7-BENZOXAZOLETHIOL

Base Information

• Chemical Name: 6-CHLORO-2-(1,1-DIMETHYLETHYL)-7-BENZOXAZOLETHIOL
• CAS No.: 954127-39-0
• Molecular Formula: C₁₁H₁₂ClNOS
• Molecular Weight: 241.741
• Mol file: 954127-39-0.mol

Synonyms:6-chloro-2-(1,1-dimethylethyl)-1,3-benzoxazole-7-thiol

Chemical Property of 6-CHLORO-2-(1,1-DIMETHYLETHYL)-7-BENZOXAZOLETHIOL

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

6-chloro-2-(1,1-Dimethylethyl)-1,3-benzoxazole-7-thiol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-CHLORO-2-(1,1-DIMETHYLETHYL)-7-BENZOXAZOLETHIOL

There total 1 articles about 6-CHLORO-2-(1,1-DIMETHYLETHYL)-7-BENZOXAZOLETHIOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

N-(3,4-dichlorophenyl)2,2-dimethyl-propionamide (7160-22-7) → 6-chloro-2-(1,1-dimethylethyl)-1,3-benzoxazole-7-thiol (954127-39-0)

Guidance literature:

N-(3,4-dichlorophenyl)2,2-dimethyl-propionamide; With n-butyllithium; In tetrahydrofuran; hexane; at -75 - 5 ℃; for 1.5h;

With sulfur; In tetrahydrofuran; hexane; at -70 - 20 ℃; Product distribution / selectivity;

Reference yield:

2-chloromethylpyridine (4377-33-7) + 6-chloro-2-(1,1-dimethylethyl)-1,3-benzoxazole-7-thiol (954127-39-0) → 2-(tert-butyl)-6-chloro-7-((pyridin-2-ylmethyl)thio)benzo[d]oxazole

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 3h;

Reference yield:

6-chloro-2-(1,1-dimethylethyl)-1,3-benzoxazole-7-thiol (954127-39-0) + 5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-6-yl methanesulfonate → N-(4-chloro-2-hydroxy-3-((5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-6-yl)thio)phenyl)pivalamide

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 95 ℃; for 16h;

upstream raw materials:

N-(3,4-dichlorophenyl)2,2-dimethyl-propionamide