1-[3-(1H-imidazol-1-yl)phenyl]piperidine-2-acetic acid ethyl ester

Base Information

• Chemical Name: 1-[3-(1H-imidazol-1-yl)phenyl]piperidine-2-acetic acid ethyl ester
• CAS No.: 212650-35-6
• Molecular Formula: C₁₈H₂₃N₃O₂
• Molecular Weight: 313.4
• Mol file: 212650-35-6.mol

Synonyms:1-[3-(1H-imidazol-1-yl)phenyl]piperidine-2-acetic acid ethyl ester

Chemical Property of 1-[3-(1H-imidazol-1-yl)phenyl]piperidine-2-acetic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 1-[3-(1H-imidazol-1-yl)phenyl]piperidine-2-acetic acid ethyl ester

There total 4 articles about 1-[3-(1H-imidazol-1-yl)phenyl]piperidine-2-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-[3-(1H-imidazol-1-yl)phenyl]piperidine-2-acrylic acid ethyl ester → 1-[3-(1H-imidazol-1-yl)phenyl]piperidine-2-acetic acid ethyl ester (212650-35-6)

Guidance literature:

With H₂; palladium-carbon; In methanol;

Reference yield:

[1-[3-(1H-imidazol-1-yl)phenyl]-2-piperidinylidine]ethanoic acid ethyl ester → 1-[3-(1H-imidazol-1-yl)phenyl]piperidine-2-acetic acid ethyl ester (212650-35-6)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 60h; under 760 Torr;

DOI:10.1021/jm061319i

Reference yield:

2-(3-chloropropyl)-acetoacetic acid ethyl ester (99054-01-0) → 1-[3-(1H-imidazol-1-yl)phenyl]piperidine-2-acetic acid ethyl ester (212650-35-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 8 percent / Na₂HPO₄; iodine; molecular sieve 4 Angstroem / benzene / Heating

2: H₂ / Pd/C / methanol / 60 h / 760 Torr

With disodium hydrogenphosphate; 4 A molecular sieve; hydrogen; iodine; palladium on activated charcoal; In methanol; benzene;

DOI:10.1021/jm061319i

upstream raw materials:

2-(3-chloropropyl)-acetoacetic acid ethyl ester

3-(1H-imidazol-1-yl)aniline