1-(4-methoxycarboxy-2-aminophenyl)-5-(tert-butyloxycarbonylaminomethyl)pyrrolidin-2-one

Base Information

Chemical Name:1-(4-methoxycarboxy-2-aminophenyl)-5-(tert-butyloxycarbonylaminomethyl)pyrrolidin-2-one
CAS No.:221382-01-0
Molecular Formula:C₁₈H₂₅N₃O₅
Molecular Weight:363.414
Hs Code.:

Synonyms:1-(4-methoxycarboxy-2-aminophenyl)-5-(tert-butyloxycarbonylaminomethyl)pyrrolidin-2-one

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Chemical Property of 1-(4-methoxycarboxy-2-aminophenyl)-5-(tert-butyloxycarbonylaminomethyl)pyrrolidin-2-one

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Technology Process of 1-(4-methoxycarboxy-2-aminophenyl)-5-(tert-butyloxycarbonylaminomethyl)pyrrolidin-2-one

There total 6 articles about 1-(4-methoxycarboxy-2-aminophenyl)-5-(tert-butyloxycarbonylaminomethyl)pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 221382-00-9
1-(4-methoxycarboxy-2-nitrophenyl)-5-(azidomethyl)pyrrolidin-2-one

: 221382-01-0
1-(4-methoxycarboxy-2-aminophenyl)-5-(tert-butyloxycarbonylaminomethyl)pyrrolidin-2-one

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; for 2.5h; under 1551.44 Torr;
DOI:10.1021/jm980707k

Reference yield:

: 453-71-4
3-nitro-4-fluorobenzoic acid

: 221382-01-0
1-(4-methoxycarboxy-2-aminophenyl)-5-(tert-butyloxycarbonylaminomethyl)pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaH / 1.) DMF, 75 deg C, 15 min, 2.) DMF, RT, 20 h

2: 96 percent / H₂SO₄ / 12 h / Heating

3: 100 percent / H₂ / 10 percent Pd/C / ethyl acetate / 2.5 h / 1551.44 Torr

With sulfuric acid; hydrogen; sodium hydride; palladium on activated charcoal; In ethyl acetate;
DOI:10.1021/jm980707k

Reference yield:

: 113466-82-3
5-(azidomethyl)-2-pyrrolidinone

: 221382-01-0
1-(4-methoxycarboxy-2-aminophenyl)-5-(tert-butyloxycarbonylaminomethyl)pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaH / 1.) DMF, 75 deg C, 15 min, 2.) DMF, RT, 20 h

2: 96 percent / H₂SO₄ / 12 h / Heating

3: 100 percent / H₂ / 10 percent Pd/C / ethyl acetate / 2.5 h / 1551.44 Torr

With sulfuric acid; hydrogen; sodium hydride; palladium on activated charcoal; In ethyl acetate;
DOI:10.1021/jm980707k