2-hydroxyl-3,3-diphenyl-4-benzyloxy butyronitrile

Base Information

Chemical Name:2-hydroxyl-3,3-diphenyl-4-benzyloxy butyronitrile
CAS No.:1314863-89-2
Molecular Formula:C₂₃H₂₁NO₂
Molecular Weight:343.425
Hs Code.:

Synonyms:2-hydroxyl-3,3-diphenyl-4-benzyloxy butyronitrile

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Chemical Property of 2-hydroxyl-3,3-diphenyl-4-benzyloxy butyronitrile

Chemical Property:

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Technology Process of 2-hydroxyl-3,3-diphenyl-4-benzyloxy butyronitrile

There total 4 articles about 2-hydroxyl-3,3-diphenyl-4-benzyloxy butyronitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 773837-37-9
sodium cyanide

: 1314863-88-1
2,2-diphenyl-3-benzyloxy propylaldehyde

: 1314863-89-2
2-hydroxyl-3,3-diphenyl-4-benzyloxy butyronitrile

Guidance literature:: 2,2-diphenyl-3-benzyloxy propylaldehyde; With sodium hydrogensulfite; In tetrahydrofuran; water; at 20 ℃; for 0.5h;

sodium cyanide; In tetrahydrofuran; water; at 20 ℃;
DOI:10.1016/j.bmcl.2011.05.034

Reference yield:

: 1314863-87-0
2,2-diphenyl-3-benzyloxy propionitrile

: 1314863-89-2
2-hydroxyl-3,3-diphenyl-4-benzyloxy butyronitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: diisobutylaluminium hydride / toluene / 0 - 20 °C / Inert atmosphere

2.1: sodium hydrogensulfite / tetrahydrofuran; water / 0.5 h / 20 °C

2.2: 20 °C

With diisobutylaluminium hydride; sodium hydrogensulfite; In tetrahydrofuran; water; toluene;
DOI:10.1016/j.bmcl.2011.05.034

Reference yield:

: 86-29-3
Diphenylacetonitrile

: 1314863-89-2
2-hydroxyl-3,3-diphenyl-4-benzyloxy butyronitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: water; calcium oxide / tetrahydrofuran / 30 °C

2.1: trifluorormethanesulfonic acid / dichloromethane; cyclohexane / 1 h / 20 °C

3.1: diisobutylaluminium hydride / toluene / 0 - 20 °C / Inert atmosphere

4.1: sodium hydrogensulfite / tetrahydrofuran; water / 0.5 h / 20 °C

4.2: 20 °C

With trifluorormethanesulfonic acid; water; diisobutylaluminium hydride; sodium hydrogensulfite; calcium oxide; In tetrahydrofuran; dichloromethane; cyclohexane; water; toluene;
DOI:10.1016/j.bmcl.2011.05.034