ethyl 5-{[(benzoylamino)carbonothioyl]amino}-1-(2-phenylethyl)-1H-pyrazole-4-carboxylate

Base Information

• Chemical Name: ethyl 5-{[(benzoylamino)carbonothioyl]amino}-1-(2-phenylethyl)-1H-pyrazole-4-carboxylate
• CAS No.: 1338789-15-3
• Molecular Formula: C₂₂H₂₂N₄O₃S
• Molecular Weight: 422.508

Synonyms:ethyl 5-{[(benzoylamino)carbonothioyl]amino}-1-(2-phenylethyl)-1H-pyrazole-4-carboxylate

Chemical Property of ethyl 5-{[(benzoylamino)carbonothioyl]amino}-1-(2-phenylethyl)-1H-pyrazole-4-carboxylate

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Technology Process of ethyl 5-{[(benzoylamino)carbonothioyl]amino}-1-(2-phenylethyl)-1H-pyrazole-4-carboxylate

There total 3 articles about ethyl 5-{[(benzoylamino)carbonothioyl]amino}-1-(2-phenylethyl)-1H-pyrazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

ethyl 5-amino-1-(2-phenylethyl)-1H-pyrazole-4-carboxylate (252903-25-6) + Benzoyl isothiocyanate (532-55-8) → ethyl 5-{[(benzoylamino)carbonothioyl]amino}-1-(2-phenylethyl)-1H-pyrazole-4-carboxylate (1338789-15-3)

Guidance literature:

In tetrahydrofuran; for 12h; Reflux;

DOI:10.1016/j.bmcl.2011.07.079

Reference yield:

Phenelzine (51-71-8) → ethyl 5-{[(benzoylamino)carbonothioyl]amino}-1-(2-phenylethyl)-1H-pyrazole-4-carboxylate (1338789-15-3)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene / 8 h / 80 °C

2: tetrahydrofuran / 12 h / Reflux

In tetrahydrofuran; toluene;

DOI:10.1016/j.bmcl.2011.07.079

Reference yield:

ethyl (ethoxymethylene)cyanoacetate (94-05-3,42466-69-3) → ethyl 5-{[(benzoylamino)carbonothioyl]amino}-1-(2-phenylethyl)-1H-pyrazole-4-carboxylate (1338789-15-3)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene / 8 h / 80 °C

2: tetrahydrofuran / 12 h / Reflux

In tetrahydrofuran; toluene;

DOI:10.1016/j.bmcl.2011.07.079

upstream raw materials:

ethyl 5-amino-1-(2-phenylethyl)-1H-pyrazole-4-carboxylate

Benzoyl isothiocyanate

Phenelzine

ethyl (ethoxymethylene)cyanoacetate

Downstream raw materials:

1-(2-phenylethyl)-6-thioxo-1,5,6,7-tetrahydro-4H-pyrazolo[3,4-d]pyrimidin-4-one

6-(methylthio)-1-(2-phenylethyl)-1,5-dihydro-4H-pyrazolo[3,4-d]-pyrimidin-4-one

4-chloro-6-(methylthio)-1-(2-phenylethyl)-1H-pyrazolo[3,4-d]-pyrimidine

N-(3-chlorophenyl)-6-(methylthio)-1-(2-phenylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

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