(2R,3R)-2-Isopropyl-6-[(R)-4-(4-methoxy-benzyloxy)-1,1,3-trimethyl-butyl]-3-methyl-2,3-dihydro-pyran-4-one

Base Information

Chemical Name:(2R,3R)-2-Isopropyl-6-[(R)-4-(4-methoxy-benzyloxy)-1,1,3-trimethyl-butyl]-3-methyl-2,3-dihydro-pyran-4-one
CAS No.:136320-71-3
Molecular Formula:C₂₄H₃₆O₄
Molecular Weight:388.547
Hs Code.:

Synonyms:(2R,3R)-2-Isopropyl-6-[(R)-4-(4-methoxy-benzyloxy)-1,1,3-trimethyl-butyl]-3-methyl-2,3-dihydro-pyran-4-one

Suppliers and Price of (2R,3R)-2-Isopropyl-6-[(R)-4-(4-methoxy-benzyloxy)-1,1,3-trimethyl-butyl]-3-methyl-2,3-dihydro-pyran-4-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2R,3R)-2-Isopropyl-6-[(R)-4-(4-methoxy-benzyloxy)-1,1,3-trimethyl-butyl]-3-methyl-2,3-dihydro-pyran-4-one

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R,3R)-2-Isopropyl-6-[(R)-4-(4-methoxy-benzyloxy)-1,1,3-trimethyl-butyl]-3-methyl-2,3-dihydro-pyran-4-one

There total 13 articles about (2R,3R)-2-Isopropyl-6-[(R)-4-(4-methoxy-benzyloxy)-1,1,3-trimethyl-butyl]-3-methyl-2,3-dihydro-pyran-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 136320-70-2
(2R,8R,9R)-9-Hydroxy-1-(4-methoxy-benzyloxy)-2,4,4,8,10-pentamethyl-undecane-5,7-dione

: 136320-71-3
(2R,3R)-2-Isopropyl-6-[(R)-4-(4-methoxy-benzyloxy)-1,1,3-trimethyl-butyl]-3-methyl-2,3-dihydro-pyran-4-one

Guidance literature:: With (1S)-7,7-dimethyl-2-oxo-1-bicyclo[2.2.1]heptanesulfonic acid; In dichloromethane; at 25 ℃; for 18h;
DOI:10.1016/0040-4039(91)80594-V

Reference yield:

: 563-80-4
3-methyl-butan-2-one

: 136320-71-3
(2R,3R)-2-Isopropyl-6-[(R)-4-(4-methoxy-benzyloxy)-1,1,3-trimethyl-butyl]-3-methyl-2,3-dihydro-pyran-4-one

Guidance literature:: Multi-step reaction with 5 steps

1: 1) KH, 2) BEt₃

2: 1) LDA / 1) THF, -78 deg C, 5 min, 2) -78 deg C, 30 min, 3) H₂O

3: 97 percent / Et₃N / CH₂Cl₂ / -78 °C

4: 71 percent / H₂ (40 psi) / W-2 Raney Ni / ethanol / 9 h

5: 71 percent / ca. 1percent camphorsulfonic acid / CH₂Cl₂ / 18 h / 25 °C

With triethyl borane; hydrogen; potassium hydride; triethylamine; (1S)-7,7-dimethyl-2-oxo-1-bicyclo[2.2.1]heptanesulfonic acid; lithium diisopropyl amide; W-2 Raney Ni; In ethanol; dichloromethane;
DOI:10.1016/0040-4039(91)80594-V

Reference yield:

: 89238-99-3
O-(4-methoxybenzyl)-trichloroacetimidate

: 136320-71-3
(2R,3R)-2-Isopropyl-6-[(R)-4-(4-methoxy-benzyloxy)-1,1,3-trimethyl-butyl]-3-methyl-2,3-dihydro-pyran-4-one

Guidance literature:: Multi-step reaction with 9 steps

1: 67 percent / camphersulfonic acid / CH₂Cl₂ / 18 h / 25 °C

2: 82 percent / LiAlH₄ / tetrahydrofuran; H₂O / 0 °C

3: 90 percent / CH₂Cl₂ / 0.5 h / 0 °C

4: 94 percent / NaI, Et₃N / acetone / 4 h / Heating

5: 1) KH, 2) BEt₃

6: 1) LDA / 1) THF, -78 deg C, 5 min, 2) -78 deg C, 30 min, 3) H₂O

7: 97 percent / Et₃N / CH₂Cl₂ / -78 °C

8: 71 percent / H₂ (40 psi) / W-2 Raney Ni / ethanol / 9 h

9: 71 percent / ca. 1percent camphorsulfonic acid / CH₂Cl₂ / 18 h / 25 °C

With lithium aluminium tetrahydride; triethyl borane; camphor-10-sulfonic acid; hydrogen; potassium hydride; triethylamine; (1S)-7,7-dimethyl-2-oxo-1-bicyclo[2.2.1]heptanesulfonic acid; sodium iodide; lithium diisopropyl amide; W-2 Raney Ni; In tetrahydrofuran; ethanol; dichloromethane; water; acetone;
DOI:10.1016/0040-4039(91)80594-V