5-[13-cyclohexyl-3-methoxy-10-[[[(1-methylethyl)sulfonyl]amino]carbonyl]-7H-indolo[2,1-a][2]benzazepin-6-yl]-1-(1,1-dimethylethyl)-1H-pyrazole-4-carboxylic acid

Base Information

Chemical Name:5-[13-cyclohexyl-3-methoxy-10-[[[(1-methylethyl)sulfonyl]amino]carbonyl]-7H-indolo[2,1-a][2]benzazepin-6-yl]-1-(1,1-dimethylethyl)-1H-pyrazole-4-carboxylic acid
CAS No.:1127238-08-7
Molecular Formula:C₃₆H₄₂N₄O₆S
Molecular Weight:658.819
Hs Code.:

5-[13-cyclohexyl-3-methoxy-10-[[[(1-methylethyl)sulfonyl]amino]carbonyl]-7H-indolo[2,1-a][2]benzazepin-6-yl]-1-(1,1-dimethylethyl)-1H-pyrazole-4-carboxylic acid

Synonyms:5-[13-cyclohexyl-3-methoxy-10-[[[(1-methylethyl)sulfonyl]amino]carbonyl]-7H-indolo[2,1-a][2]benzazepin-6-yl]-1-(1,1-dimethylethyl)-1H-pyrazole-4-carboxylic acid

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Chemical Property of 5-[13-cyclohexyl-3-methoxy-10-[[[(1-methylethyl)sulfonyl]amino]carbonyl]-7H-indolo[2,1-a][2]benzazepin-6-yl]-1-(1,1-dimethylethyl)-1H-pyrazole-4-carboxylic acid

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Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 5-[13-cyclohexyl-3-methoxy-10-[[[(1-methylethyl)sulfonyl]amino]carbonyl]-7H-indolo[2,1-a][2]benzazepin-6-yl]-1-(1,1-dimethylethyl)-1H-pyrazole-4-carboxylic acid

There total 1 articles about 5-[13-cyclohexyl-3-methoxy-10-[[[(1-methylethyl)sulfonyl]amino]carbonyl]-7H-indolo[2,1-a][2]benzazepin-6-yl]-1-(1,1-dimethylethyl)-1H-pyrazole-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1127238-06-5
5-[13-cyclohexyl-3-methoxy-10-[[[(1-methylethyl)sulfonyl]amino]carbonyl]-7H-indolo[2,1-a][2]benzazepin-6-yl]-1-(1,1-dimethylethyl)-1H-pyrazole-4-carboxylic acid ethyl ester

: 1127238-08-7
5-[13-cyclohexyl-3-methoxy-10-[[[(1-methylethyl)sulfonyl]amino]carbonyl]-7H-indolo[2,1-a][2]benzazepin-6-yl]-1-(1,1-dimethylethyl)-1H-pyrazole-4-carboxylic acid

Guidance literature:: 5-[13-cyclohexyl-3-methoxy-10-[[[(1-methylethyl)sulfonyl]amino]carbonyl]-7H-indolo[2,1-a][2]benzazepin-6-yl]-1-(1,1-dimethylethyl)-1H-pyrazole-4-carboxylic acid ethyl ester; With methanol; sodium hydroxide; water; In tetrahydrofuran; at 20 ℃; for 25h;

With hydrogenchloride; water; In tetrahydrofuran; methanol; ethyl acetate;

Reference yield:

: 1127238-08-7
5-[13-cyclohexyl-3-methoxy-10-[[[(1-methylethyl)sulfonyl]amino]carbonyl]-7H-indolo[2,1-a][2]benzazepin-6-yl]-1-(1,1-dimethylethyl)-1H-pyrazole-4-carboxylic acid

: 141-91-3,6485-45-6,6485-55-8
cis-2,6-dimethylmorpholine

: 1127238-09-8
13-cyclohexyl-6-[1-(1,1-dimethylethyl)-4-[[(2R,6S)-2,6-dimethyl-4-morpholinyl]carbonyl]-1H-pyrazol-5-yl]-3-methoxy-N-[(1-methylethyl)sulfonyl]-7H-indolo[2,1-a][2]benzazepine-10-carboxamide

Guidance literature:: 5-[13-cyclohexyl-3-methoxy-10-[[[(1-methylethyl)sulfonyl]amino]carbonyl]-7H-indolo[2,1-a][2]benzazepin-6-yl]-1-(1,1-dimethylethyl)-1H-pyrazole-4-carboxylic acid; With HATU; In N,N-dimethyl-formamide; at 20 ℃; for 1.25h;

cis-2,6-dimethylmorpholine; With dmap; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

Reference yield:

: (2R,6S)-1,2,6-trimethylpiperazine dihydrochloride

: 1127238-08-7
5-[13-cyclohexyl-3-methoxy-10-[[[(1-methylethyl)sulfonyl]amino]carbonyl]-7H-indolo[2,1-a][2]benzazepin-6-yl]-1-(1,1-dimethylethyl)-1H-pyrazole-4-carboxylic acid

: 1127238-11-2
13-cyclohexyl-6-[1-(1,1-dimethylethyl)-4-[[(3R,5S)-3,4,5-trimethyl-1-piperazinyl]carbonyl]-1H-pyrazol-5-yl]-3-methoxy-N-[(1-methylethyl)sulfonyl]-7H-indolo[2,1-a][2]benzazepine-10-carboxamide

Guidance literature:: 5-[13-cyclohexyl-3-methoxy-10-[[[(1-methylethyl)sulfonyl]amino]carbonyl]-7H-indolo[2,1-a][2]benzazepin-6-yl]-1-(1,1-dimethylethyl)-1H-pyrazole-4-carboxylic acid; With HATU; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

(2R,6S)-1,2,6-trimethylpiperazine dihydrochloride; With dmap; In N,N-dimethyl-formamide; at 20 ℃; for 18h;