C₂₀H₂₇BrN₄O₄

Base Information

• Chemical Name: C₂₀H₂₇BrN₄O₄
• CAS No.: 1588405-36-0
• Molecular Formula: C₂₀H₂₇BrN₄O₄
• Molecular Weight: 467.363
• Mol file: 1588405-36-0.mol

Synonyms:C₂₀H₂₇BrN₄O₄

Chemical Property of C₂₀H₂₇BrN₄O₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₀H₂₇BrN₄O₄

There total 10 articles about C₂₀H₂₇BrN₄O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

(3S)-2-((S)-2-(methoxycarbonylamino)-3-methylbutanoyl)-2-azabicyclo[2.2.1]heptane-3-carboxylic acid (1292838-04-0) + 4-Bromo-benzene-1,2-diamine (1575-37-7) → C20H27BrN4O4 (1588405-36-0)

Guidance literature:

(3S)-2-((S)-2-(methoxycarbonylamino)-3-methylbutanoyl)-2-azabicyclo[2.2.1]heptane-3-carboxylic acid; With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; at 0 ℃; for 0.5h;

4-Bromo-benzene-1,2-diamine; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield:

C14H22N2O5 (1258235-17-4) + 4-Bromo-benzene-1,2-diamine (1575-37-7) → C20H27BrN4O4 (1588405-36-0)

Guidance literature:

C₁₄H₂₂N₂O₅; With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; at 20 ℃; for 0.5h; Cooling with ice; Inert atmosphere;

4-Bromo-benzene-1,2-diamine; In tetrahydrofuran; at 20 ℃; for 2h; Inert atmosphere;

Reference yield:

N-methoxycarbonyl-L-valine (111398-44-8,74761-42-5) → C20H27BrN4O4 (1588405-36-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 20 °C / Cooling with ice

2.1: lithium hydroxide / tetrahydrofuran; water / 12 h / 40 °C / Cooling with ice

3.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / tetrahydrofuran / 0.5 h / 20 °C / Cooling with ice; Inert atmosphere

3.2: 2 h / 20 °C / Inert atmosphere

With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; lithium hydroxide; In tetrahydrofuran; dichloromethane; water;

upstream raw materials:

(3S)-2-((S)-2-(methoxycarbonylamino)-3-methylbutanoyl)-2-azabicyclo[2.2.1]heptane-3-carboxylic acid

4-Bromo-benzene-1,2-diamine

N-methoxycarbonyl-L-valine

L-valine