1-benzyl-2-((E)-5-(4-trifluoromethylphenyl)pent-4-enyl)-3-(propan-2-ylidene)aziridine

Base Information

Chemical Name:1-benzyl-2-((E)-5-(4-trifluoromethylphenyl)pent-4-enyl)-3-(propan-2-ylidene)aziridine
CAS No.:1356855-97-4
Molecular Formula:C₂₄H₂₆F₃N
Molecular Weight:385.472
Hs Code.:

Synonyms:1-benzyl-2-((E)-5-(4-trifluoromethylphenyl)pent-4-enyl)-3-(propan-2-ylidene)aziridine

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Chemical Property of 1-benzyl-2-((E)-5-(4-trifluoromethylphenyl)pent-4-enyl)-3-(propan-2-ylidene)aziridine

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Technology Process of 1-benzyl-2-((E)-5-(4-trifluoromethylphenyl)pent-4-enyl)-3-(propan-2-ylidene)aziridine

There total 1 articles about 1-benzyl-2-((E)-5-(4-trifluoromethylphenyl)pent-4-enyl)-3-(propan-2-ylidene)aziridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 838867-84-8
1-benzyl-2-(1-methylethylidene)aziridine

: 824431-59-6
1-((E)-5-iodopent-1-enyl)-4-trifluorotoluene

: 1356855-97-4
1-benzyl-2-((E)-5-(4-trifluoromethylphenyl)pent-4-enyl)-3-(propan-2-ylidene)aziridine

Guidance literature:: 1-benzyl-2-(1-methylethylidene)aziridine; With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; In tetrahydrofuran; at -78 ℃; for 6h; Inert atmosphere;

1-((E)-5-iodopent-1-enyl)-4-trifluorotoluene; In tetrahydrofuran; at -78 ℃; Inert atmosphere;
DOI:10.1039/c1ob06578e

Reference yield:

: 1356855-97-4
1-benzyl-2-((E)-5-(4-trifluoromethylphenyl)pent-4-enyl)-3-(propan-2-ylidene)aziridine

: C₂₄H₂₇F₃N⁽¹⁺⁾

Guidance literature:: 1-benzyl-2-((E)-5-(4-trifluoromethylphenyl)pent-4-enyl)-3-(propan-2-ylidene)aziridine; With boron trifluoride diethyl etherate; In dichloromethane; at -30 - 20 ℃; for 15h;

With sodium hydrogencarbonate; In water; diastereoselective reaction;
DOI:10.1039/c1ob06578e

Reference yield:

: 1356855-97-4
1-benzyl-2-((E)-5-(4-trifluoromethylphenyl)pent-4-enyl)-3-(propan-2-ylidene)aziridine

: rac-(1S,3R,3aR,6aS)-2-benzyloctahydro-1-isopropyl-3-(4-trifluoromethylphenyl)cyclopenta[c]pyrrole

: rac-(1R,3R,3aR,6aS)-2-benzyloctahydro-1-isopropyl-3-(4-trifluoromethylphenyl)cyclopenta[c]pyrrole

Guidance literature:: Multi-step reaction with 2 steps

1: boron trifluoride diethyl etherate / dichloromethane / 15 h / -30 - 20 °C

2: sodium tetrahydroborate; acetic acid / tetrahydrofuran / 12 h / 20 °C

With sodium tetrahydroborate; boron trifluoride diethyl etherate; acetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1039/c1ob06578e