(E)-methyl 2-((2S,3S,6S)-3-acetoxy-2-((E)-4-((2R,6S)-6-(((2S,4S,6R)-4-acetoxy-6-((R)-4-(tert-butylthio)-2-hydroxy-4-oxobutyl)-2-methoxy-3,3-dimethyltetrahydro-2H-pyran-2-yl)methyl)-4-methylenetetrahydro-2H-pyran-2-yl)-2-methylbut-3-en-2-yl)-6-((2R,3R)-3-((benzyloxy)methoxy)-2-((4-methoxybenzyl)oxy)butyl)-2-methoxydihydro-2H-pyran-4(3H)-ylidene) acetate

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Chemical Name:(E)-methyl 2-((2S,3S,6S)-3-acetoxy-2-((E)-4-((2R,6S)-6-(((2S,4S,6R)-4-acetoxy-6-((R)-4-(tert-butylthio)-2-hydroxy-4-oxobutyl)-2-methoxy-3,3-dimethyltetrahydro-2H-pyran-2-yl)methyl)-4-methylenetetrahydro-2H-pyran-2-yl)-2-methylbut-3-en-2-yl)-6-((2R,3R)-3-((benzyloxy)methoxy)-2-((4-methoxybenzyl)oxy)butyl)-2-methoxydihydro-2H-pyran-4(3H)-ylidene) acetate
CAS No.:1261423-15-7
Molecular Formula:C₆₁H₈₈O₁₇S
Molecular Weight:1125.43
Hs Code.:

(E)-methyl 2-((2S,3S,6S)-3-acetoxy-2-((E)-4-((2R,6S)-6-(((2S,4S,6R)-4-acetoxy-6-((R)-4-(tert-butylthio)-2-hydroxy-4-oxobutyl)-2-methoxy-3,3-dimethyltetrahydro-2H-pyran-2-yl)methyl)-4-methylenetetrahydro-2H-pyran-2-yl)-2-methylbut-3-en-2-yl)-6-((2R,3R)-3-((benzyloxy)methoxy)-2-((4-methoxybenzyl)oxy)butyl)-2-methoxydihydro-2H-pyran-4(3H)-ylidene) acetate

Synonyms:(E)-methyl 2-((2S,3S,6S)-3-acetoxy-2-((E)-4-((2R,6S)-6-(((2S,4S,6R)-4-acetoxy-6-((R)-4-(tert-butylthio)-2-hydroxy-4-oxobutyl)-2-methoxy-3,3-dimethyltetrahydro-2H-pyran-2-yl)methyl)-4-methylenetetrahydro-2H-pyran-2-yl)-2-methylbut-3-en-2-yl)-6-((2R,3R)-3-((benzyloxy)methoxy)-2-((4-methoxybenzyl)oxy)butyl)-2-methoxydihydro-2H-pyran-4(3H)-ylidene) acetate

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Chemical Property of (E)-methyl 2-((2S,3S,6S)-3-acetoxy-2-((E)-4-((2R,6S)-6-(((2S,4S,6R)-4-acetoxy-6-((R)-4-(tert-butylthio)-2-hydroxy-4-oxobutyl)-2-methoxy-3,3-dimethyltetrahydro-2H-pyran-2-yl)methyl)-4-methylenetetrahydro-2H-pyran-2-yl)-2-methylbut-3-en-2-yl)-6-((2R,3R)-3-((benzyloxy)methoxy)-2-((4-methoxybenzyl)oxy)butyl)-2-methoxydihydro-2H-pyran-4(3H)-ylidene) acetate

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Technology Process of (E)-methyl 2-((2S,3S,6S)-3-acetoxy-2-((E)-4-((2R,6S)-6-(((2S,4S,6R)-4-acetoxy-6-((R)-4-(tert-butylthio)-2-hydroxy-4-oxobutyl)-2-methoxy-3,3-dimethyltetrahydro-2H-pyran-2-yl)methyl)-4-methylenetetrahydro-2H-pyran-2-yl)-2-methylbut-3-en-2-yl)-6-((2R,3R)-3-((benzyloxy)methoxy)-2-((4-methoxybenzyl)oxy)butyl)-2-methoxydihydro-2H-pyran-4(3H)-ylidene) acetate

There total 1 articles about (E)-methyl 2-((2S,3S,6S)-3-acetoxy-2-((E)-4-((2R,6S)-6-(((2S,4S,6R)-4-acetoxy-6-((R)-4-(tert-butylthio)-2-hydroxy-4-oxobutyl)-2-methoxy-3,3-dimethyltetrahydro-2H-pyran-2-yl)methyl)-4-methylenetetrahydro-2H-pyran-2-yl)-2-methylbut-3-en-2-yl)-6-((2R,3R)-3-((benzyloxy)methoxy)-2-((4-methoxybenzyl)oxy)butyl)-2-methoxydihydro-2H-pyran-4(3H)-ylidene) acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1261423-13-5
(E)-methyl 2-((2S,3S,6S)-3-acetoxy-2-((E)-4-((2R,6S)-6-(((2S,4S,6S)-4-acetoxy-6-((R)-2-((tert-butyldiphenylsilyl)oxy)-4-(tert-butylthio)-4-oxobutyl)-2-methoxy-3,3-dimethyltetrahydro-2H-pyran-2-yl)methyl)-4-methylenetetrahydro-2H-pyran-2-yl)-2-methylbut-3-en-2-yl)-6-((2R,3R)-3-((benzyloxy)methoxy)-2-((4-methoxybenzyl)oxy)butyl)-2-methoxydihydro-2H-pyran-4(3H)-ylidene) acetate

: 1261423-15-7
(E)-methyl 2-((2S,3S,6S)-3-acetoxy-2-((E)-4-((2R,6S)-6-(((2S,4S,6R)-4-acetoxy-6-((R)-4-(tert-butylthio)-2-hydroxy-4-oxobutyl)-2-methoxy-3,3-dimethyltetrahydro-2H-pyran-2-yl)methyl)-4-methylenetetrahydro-2H-pyran-2-yl)-2-methylbut-3-en-2-yl)-6-((2R,3R)-3-((benzyloxy)methoxy)-2-((4-methoxybenzyl)oxy)butyl)-2-methoxydihydro-2H-pyran-4(3H)-ylidene) acetate

Guidance literature:: With pyridine; pyridine hydrogenfluoride; In tetrahydrofuran; methanol; at 0 - 20 ℃;
DOI:10.1021/ja110198y

Reference yield:

: 1261423-15-7
(E)-methyl 2-((2S,3S,6S)-3-acetoxy-2-((E)-4-((2R,6S)-6-(((2S,4S,6R)-4-acetoxy-6-((R)-4-(tert-butylthio)-2-hydroxy-4-oxobutyl)-2-methoxy-3,3-dimethyltetrahydro-2H-pyran-2-yl)methyl)-4-methylenetetrahydro-2H-pyran-2-yl)-2-methylbut-3-en-2-yl)-6-((2R,3R)-3-((benzyloxy)methoxy)-2-((4-methoxybenzyl)oxy)butyl)-2-methoxydihydro-2H-pyran-4(3H)-ylidene) acetate

: C₅₇H₈₀O₁₈

Guidance literature:: With water; dihydrogen peroxide; lithium hydroxide; In tetrahydrofuran; at 0 ℃; for 1h;
DOI:10.1021/ja110198y

Reference yield:

: 1261423-15-7
(E)-methyl 2-((2S,3S,6S)-3-acetoxy-2-((E)-4-((2R,6S)-6-(((2S,4S,6R)-4-acetoxy-6-((R)-4-(tert-butylthio)-2-hydroxy-4-oxobutyl)-2-methoxy-3,3-dimethyltetrahydro-2H-pyran-2-yl)methyl)-4-methylenetetrahydro-2H-pyran-2-yl)-2-methylbut-3-en-2-yl)-6-((2R,3R)-3-((benzyloxy)methoxy)-2-((4-methoxybenzyl)oxy)butyl)-2-methoxydihydro-2H-pyran-4(3H)-ylidene) acetate

: 1261423-19-1
(3S,7R,8E,11S,12S,13E,15S,17R,21R,23S,25S)-17-((R)-1-((benzyloxy)methoxy)ethyl)-1,11-dimethoxy-13-(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-5-methylene-19-oxo-21-((triethylsilyl)oxy)-18,27,28,29-tetraoxatetracyclo[21.3.1.13,7.111,15]nonacos-8-ene-12,25-diyl diacetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: water; dihydrogen peroxide; lithium hydroxide / tetrahydrofuran / 1 h / 0 °C

2.1: dmap / dichloromethane / 1 h / -15 °C

3.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 0 °C / pH 8 / aq. phosphate buffer

4.1: 2,4,6-trichlorobenzoyl chloride; triethylamine / tetrahydrofuran / 0 - 20 °C

4.2: 14 h / 40 °C

With dmap; 2,4,6-trichlorobenzoyl chloride; water; dihydrogen peroxide; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; lithium hydroxide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja110198y