(3-chloro-phenyl)-(3,3-dimethyl-piperazin-1-yl)-methanone trifluoroacetate

Base Information

• Chemical Name: (3-chloro-phenyl)-(3,3-dimethyl-piperazin-1-yl)-methanone trifluoroacetate
• CAS No.: 1443759-11-2
• Molecular Formula: C₂HF₃O₂*C₁₃H₁₇ClN₂O
• Molecular Weight: 366.768
• Mol file: 1443759-11-2.mol

Synonyms:(3-chloro-phenyl)-(3,3-dimethyl-piperazin-1-yl)-methanone trifluoroacetate

Chemical Property of (3-chloro-phenyl)-(3,3-dimethyl-piperazin-1-yl)-methanone trifluoroacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3-chloro-phenyl)-(3,3-dimethyl-piperazin-1-yl)-methanone trifluoroacetate

There total 4 articles about (3-chloro-phenyl)-(3,3-dimethyl-piperazin-1-yl)-methanone trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

4-(3-chloro-benzoyl)-2,2-dimethyl-piperazine-1-carboxylic acid benzyl ester (1443759-10-1) + trifluoroacetic acid (76-05-1) → (3-chloro-phenyl)-(3,3-dimethyl-piperazin-1-yl)-methanone trifluoroacetate (1443759-11-2)

Guidance literature:

4-(3-chloro-benzoyl)-2,2-dimethyl-piperazine-1-carboxylic acid benzyl ester; With hydrogen bromide; acetic acid; at 20 ℃;

trifluoroacetic acid; In dichloromethane;

Reference yield:

2,2-dimethyl-piperazine-1-carboxylic acid benzyl ester trifluoroacetate (1443758-97-1) → (3-chloro-phenyl)-(3,3-dimethyl-piperazin-1-yl)-methanone trifluoroacetate (1443759-11-2)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / ethyl acetate / 20 °C

2: acetic acid; hydrogen bromide / 20 °C

With hydrogen bromide; acetic acid; N-ethyl-N,N-diisopropylamine; In ethyl acetate;

Reference yield:

2,2-dimethyl-piperazine-1,4-dicarboxylic acid 1-benzyl ester 4-tert-butyl ester (1400761-07-0) → (3-chloro-phenyl)-(3,3-dimethyl-piperazin-1-yl)-methanone trifluoroacetate (1443759-11-2)

Guidance literature:

Multi-step reaction with 3 steps

1: dichloromethane / 20 °C

2: N-ethyl-N,N-diisopropylamine / ethyl acetate / 20 °C

3: acetic acid; hydrogen bromide / 20 °C

With hydrogen bromide; acetic acid; N-ethyl-N,N-diisopropylamine; In dichloromethane; ethyl acetate;

upstream raw materials:

2,2-dimethyl-piperazine-1-carboxylic acid benzyl ester trifluoroacetate

2,2-dimethyl-piperazine-1,4-dicarboxylic acid 1-benzyl ester 4-tert-butyl ester

3,3-dimethyl-piperazine-1-carboxylic acid tert-butyl ester

4-(3-chloro-benzoyl)-2,2-dimethyl-piperazine-1-carboxylic acid benzyl ester

Downstream raw materials:

[4-(3-chloro-benzoyl)-2,2-dimethyl-piperazin-1-yl]-(1-phenyl-1H-[1,2,4]-triazol-3-yl)-methanone

Refernces

• 1、 -. "NOVEL COMPOUNDS". . . Retrieved 2013/06/28.