5-(5-{4-[5-(tert-butoxycarbonylaminomethyl)thiophen-2-yl]thieno[3,2-d]pyrimidin-6-yl}-2-methoxypyridin-3-ylsulfamoyl)-2-methoxybenzoic acid

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Chemical Name:5-(5-{4-[5-(tert-butoxycarbonylaminomethyl)thiophen-2-yl]thieno[3,2-d]pyrimidin-6-yl}-2-methoxypyridin-3-ylsulfamoyl)-2-methoxybenzoic acid
CAS No.:1414472-82-4
Molecular Formula:C₃₀H₂₉N₅O₈S₃
Molecular Weight:683.787
Hs Code.:

Synonyms:5-(5-{4-[5-(tert-butoxycarbonylaminomethyl)thiophen-2-yl]thieno[3,2-d]pyrimidin-6-yl}-2-methoxypyridin-3-ylsulfamoyl)-2-methoxybenzoic acid

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Chemical Property of 5-(5-{4-[5-(tert-butoxycarbonylaminomethyl)thiophen-2-yl]thieno[3,2-d]pyrimidin-6-yl}-2-methoxypyridin-3-ylsulfamoyl)-2-methoxybenzoic acid

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Technology Process of 5-(5-{4-[5-(tert-butoxycarbonylaminomethyl)thiophen-2-yl]thieno[3,2-d]pyrimidin-6-yl}-2-methoxypyridin-3-ylsulfamoyl)-2-methoxybenzoic acid

There total 5 articles about 5-(5-{4-[5-(tert-butoxycarbonylaminomethyl)thiophen-2-yl]thieno[3,2-d]pyrimidin-6-yl}-2-methoxypyridin-3-ylsulfamoyl)-2-methoxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 51904-91-7
5-chlorosulfonyl-2-anisic acid

: 1414468-76-0
{5-[6-(5-amino-6-methoxypyridin-3-yl)thieno[3,2-d]pyrimidin-4-yl]thiophen-2-ylmethyl}carbamic acid tert-butyl ester

: 1414472-82-4
5-(5-{4-[5-(tert-butoxycarbonylaminomethyl)thiophen-2-yl]thieno[3,2-d]pyrimidin-6-yl}-2-methoxypyridin-3-ylsulfamoyl)-2-methoxybenzoic acid

Guidance literature:: With pyridine; at 0 - 20 ℃; for 3.5h;
DOI:10.1021/acsmedchemlett.1c00412

Reference yield: 56.0%

: 1414472-82-4
5-(5-{4-[5-(tert-butoxycarbonylaminomethyl)thiophen-2-yl]thieno[3,2-d]pyrimidin-6-yl}-2-methoxypyridin-3-ylsulfamoyl)-2-methoxybenzoic acid

Guidance literature:

Reference yield:

: 16269-66-2
4-chlorothieno[3,2-d]pyrimidine

: 1414472-82-4
5-(5-{4-[5-(tert-butoxycarbonylaminomethyl)thiophen-2-yl]thieno[3,2-d]pyrimidin-6-yl}-2-methoxypyridin-3-ylsulfamoyl)-2-methoxybenzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C

1.2: 2 h / -50 °C

2.1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / water; 1,4-dioxane / 2 h / 120 °C / Sealed tube

3.1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / water; 1,4-dioxane / 1 h / 100 °C / Sealed tube

4.1: pyridine / 3.5 h / 0 - 20 °C

With pyridine; bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; water; 2.1: |Suzuki Coupling / 3.1: |Suzuki Coupling;
DOI:10.1021/acsmedchemlett.1c00412