(E)-5-(p-methoxybenzyloxy)-1-(tert-butyldiphenylsilyloxymethyl)-2-(tert-butyldimethylsilyloxy)-3-methylpent-2-ene

Base Information

• Chemical Name: (E)-5-(p-methoxybenzyloxy)-1-(tert-butyldiphenylsilyloxymethyl)-2-(tert-butyldimethylsilyloxy)-3-methylpent-2-ene
• CAS No.: 554416-27-2
• Molecular Formula: C₃₇H₅₄O₄Si₂
• Molecular Weight: 619.004

Synonyms:(E)-5-(p-methoxybenzyloxy)-1-(tert-butyldiphenylsilyloxymethyl)-2-(tert-butyldimethylsilyloxy)-3-methylpent-2-ene

Chemical Property of (E)-5-(p-methoxybenzyloxy)-1-(tert-butyldiphenylsilyloxymethyl)-2-(tert-butyldimethylsilyloxy)-3-methylpent-2-ene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-5-(p-methoxybenzyloxy)-1-(tert-butyldiphenylsilyloxymethyl)-2-(tert-butyldimethylsilyloxy)-3-methylpent-2-ene

There total 8 articles about (E)-5-(p-methoxybenzyloxy)-1-(tert-butyldiphenylsilyloxymethyl)-2-(tert-butyldimethylsilyloxy)-3-methylpent-2-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tert-butylchlorodiphenylsilane (58479-61-1) + 2-(tert-butyl-dimethyl-silanyloxymethyl)-5-(4-methoxy-benzyloxy)-3-methyl-pent-2-en-1-ol (554416-42-1) → (E)-5-(p-methoxybenzyloxy)-1-(tert-butyldiphenylsilyloxymethyl)-2-(tert-butyldimethylsilyloxy)-3-methylpent-2-ene (554416-27-2)

Guidance literature:

With 1H-imidazole; In dichloromethane; at 0 - 20 ℃;

DOI:10.1016/S0040-4020(03)00372-7

Reference yield:

4-methoxybenzyl iodide (70887-29-5) → (E)-5-(p-methoxybenzyloxy)-1-(tert-butyldiphenylsilyloxymethyl)-2-(tert-butyldimethylsilyloxy)-3-methylpent-2-ene (554416-27-2)

Guidance literature:

Multi-step reaction with 8 steps

1.1: 68 percent / sodium hydride / tetrahydrofuran / 21 h / 20 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / -78 °C

2.2: 81 percent / tetrahydrofuran; hexane / 2 h / -78 °C

3.1: copper(I) iodide / tetrahydrofuran; diethyl ether / 0 °C

3.2: tetrahydrofuran; diethyl ether / 1 h / -78 - -45 °C

3.3: 95 percent / iodine / tetrahydrofuran; diethyl ether / 3 h / -78 - 0 °C

4.1: DIBAL-H / CH₂Cl₂; hexane / 2 h / -78 °C

5.1: 100 percent / imidazole / CH₂Cl₂ / 15 h / 20 °C

6.1: 75 percent / Et₃N / bis(triphenylphosphine)palladium(II) dichloride / 1-methyl-pyrrolidin-2-one / 44 h / 70 °C / 15514.4 Torr

7.1: 66 percent / DIBAL-H / toluene / 1.5 h / -78 °C

8.1: 100 percent / imidazole / CH₂Cl₂ / 0 - 20 °C

With 1H-imidazole; copper(l) iodide; n-butyllithium; sodium hydride; diisobutylaluminium hydride; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; diethyl ether; hexane; dichloromethane; toluene;

DOI:10.1016/S0040-4020(03)00372-7

Reference yield:

1-but-3-ynyloxymethyl-4-methoxy-benzene (218434-90-3) → (E)-5-(p-methoxybenzyloxy)-1-(tert-butyldiphenylsilyloxymethyl)-2-(tert-butyldimethylsilyloxy)-3-methylpent-2-ene (554416-27-2)

Guidance literature:

Multi-step reaction with 7 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / -78 °C

1.2: 81 percent / tetrahydrofuran; hexane / 2 h / -78 °C

2.1: copper(I) iodide / tetrahydrofuran; diethyl ether / 0 °C

2.2: tetrahydrofuran; diethyl ether / 1 h / -78 - -45 °C

2.3: 95 percent / iodine / tetrahydrofuran; diethyl ether / 3 h / -78 - 0 °C

3.1: DIBAL-H / CH₂Cl₂; hexane / 2 h / -78 °C

4.1: 100 percent / imidazole / CH₂Cl₂ / 15 h / 20 °C

5.1: 75 percent / Et₃N / bis(triphenylphosphine)palladium(II) dichloride / 1-methyl-pyrrolidin-2-one / 44 h / 70 °C / 15514.4 Torr

6.1: 66 percent / DIBAL-H / toluene / 1.5 h / -78 °C

7.1: 100 percent / imidazole / CH₂Cl₂ / 0 - 20 °C

With 1H-imidazole; copper(l) iodide; n-butyllithium; diisobutylaluminium hydride; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; diethyl ether; hexane; dichloromethane; toluene;

DOI:10.1016/S0040-4020(03)00372-7

upstream raw materials:

tert-butylchlorodiphenylsilane

2-(tert-butyl-dimethyl-silanyloxymethyl)-5-(4-methoxy-benzyloxy)-3-methyl-pent-2-en-1-ol

4-methoxybenzyl iodide

1-but-3-ynyloxymethyl-4-methoxy-benzene

Downstream raw materials:

(E)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-5-[(4R,5R)-5-((E)-2-iodo-vinyl)-2,2,5-trimethyl-[1,3]dioxan-4-yl]-3-methyl-pent-2-en-1-ol

4-[4-(tert-butyl-dimethyl-silanyloxymethyl)-5-(tert-butyl-diphenyl-silanyloxy)-3-methyl-pent-3-enyl]-2,2-dimethyl-[1,3]dioxane-5-carbaldehyde

4-[4-(tert-butyl-dimethyl-silanyloxymethyl)-5-(tert-butyl-diphenyl-silanyloxy)-3-methyl-pent-3-enyl]-2,2-dimethyl-[1,3]dioxane-5-carbonitrile

(E)-5-hydroxy-1-(tert-butyldiphenylsilyloxymethyl)-2-(tert-butyldimethylsilyloxy)-3-methylpent-2-ene

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 554416-27-2 (E)-5-(p-methoxybenzyloxy)-1-(tert-butyldiphenylsilyloxymethyl)-2-(tert-butyldimethylsilyloxy)-3-methylpent-2-ene

Send

Send

Metric Ton KG G Pound L ML

Send

Send