Acetic acid (2R,3S)-1-benzyl-2-[(R)-3-benzyloxy-1-((S)-4-isopropyl-2-oxo-oxazolidine-3-carbonyl)-propyl]-5-oxo-pyrrolidin-3-yl ester

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Chemical Name:Acetic acid (2R,3S)-1-benzyl-2-[(R)-3-benzyloxy-1-((S)-4-isopropyl-2-oxo-oxazolidine-3-carbonyl)-propyl]-5-oxo-pyrrolidin-3-yl ester
CAS No.:176376-11-7
Molecular Formula:C₃₀H₃₆N₂O₇
Molecular Weight:536.625
Hs Code.:

Synonyms:Acetic acid (2R,3S)-1-benzyl-2-[(R)-3-benzyloxy-1-((S)-4-isopropyl-2-oxo-oxazolidine-3-carbonyl)-propyl]-5-oxo-pyrrolidin-3-yl ester

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Chemical Property of Acetic acid (2R,3S)-1-benzyl-2-[(R)-3-benzyloxy-1-((S)-4-isopropyl-2-oxo-oxazolidine-3-carbonyl)-propyl]-5-oxo-pyrrolidin-3-yl ester

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Technology Process of Acetic acid (2R,3S)-1-benzyl-2-[(R)-3-benzyloxy-1-((S)-4-isopropyl-2-oxo-oxazolidine-3-carbonyl)-propyl]-5-oxo-pyrrolidin-3-yl ester

There total 1 articles about Acetic acid (2R,3S)-1-benzyl-2-[(R)-3-benzyloxy-1-((S)-4-isopropyl-2-oxo-oxazolidine-3-carbonyl)-propyl]-5-oxo-pyrrolidin-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (S)-3-(4-Benzyloxy-butyryl)-4-isopropyl-oxazolidin-2-one

: (3S)-1-benzyl-5-oxopyrrolidine-2,3-diyl diacetate

: 176376-11-7
Acetic acid (2R,3S)-1-benzyl-2-[(R)-3-benzyloxy-1-((S)-4-isopropyl-2-oxo-oxazolidine-3-carbonyl)-propyl]-5-oxo-pyrrolidin-3-yl ester

Guidance literature:: With nBuBOTf; N-ethyl-N,N-diisopropylamine; Yield given. Multistep reaction; 1) CH₂Cl₂, 0 deg C, 45 min; 2) CH₂Cl₂, 0 deg C, 15 min, rt, 4 h;
DOI:10.1021/jo9513020

Reference yield: 72.0%

: 176376-11-7
Acetic acid (2R,3S)-1-benzyl-2-[(R)-3-benzyloxy-1-((S)-4-isopropyl-2-oxo-oxazolidine-3-carbonyl)-propyl]-5-oxo-pyrrolidin-3-yl ester

: 17016-83-0
(4S)-4-isopropyl-1,3-oxazolidin-2-one

: 176376-12-8
(4S,5R,1'R)-N-benzyl-2-oxo-4-hydroxy-5-<1'-(hydroxymethyl)-3'-(benzyloxy)propyl>pyrrolidine

Guidance literature:: With lithium borohydride; In tetrahydrofuran; 1) 0 deg C, 5 min; 2) rt, 4 h;
DOI:10.1021/jo9513020

Reference yield:

: 176376-11-7
Acetic acid (2R,3S)-1-benzyl-2-[(R)-3-benzyloxy-1-((S)-4-isopropyl-2-oxo-oxazolidine-3-carbonyl)-propyl]-5-oxo-pyrrolidin-3-yl ester

: 176376-14-0
(2R,3S)-1-Benzyl-2-[(R)-3-benzyloxy-1-(tert-butyl-dimethyl-silanyloxymethyl)-propyl]-3-(tert-butyl-dimethyl-silanyloxy)-pyrrolidine

Guidance literature:: Multi-step reaction with 3 steps

1: 67 percent / LiBH₄ / tetrahydrofuran / 1) 0 deg C, 5 min; 2) rt, 4 h

2: 64 percent / 2,6-lutidine / CH₂Cl₂ / 3 h / 0 °C

3: 73 percent / BH₃Me₂S / tetrahydrofuran / 16 h / Ambient temperature

With 2,6-dimethylpyridine; lithium borohydride; dimethylsulfide borane complex; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo9513020