(3R,2'S)-2'-(1-Ethyl-1-methoxy-propyl)-3-((R)-2-nitro-1-phenyl-ethyl)-[1,1']bipyrrolidinyl-2-one

Base Information

• Chemical Name: (3R,2'S)-2'-(1-Ethyl-1-methoxy-propyl)-3-((R)-2-nitro-1-phenyl-ethyl)-[1,1']bipyrrolidinyl-2-one
• CAS No.: 406497-11-8
• Molecular Formula: C₂₂H₃₃N₃O₄
• Molecular Weight: 403.522

Synonyms:(3R,2'S)-2'-(1-Ethyl-1-methoxy-propyl)-3-((R)-2-nitro-1-phenyl-ethyl)-[1,1']bipyrrolidinyl-2-one

Chemical Property of (3R,2'S)-2'-(1-Ethyl-1-methoxy-propyl)-3-((R)-2-nitro-1-phenyl-ethyl)-[1,1']bipyrrolidinyl-2-one

Chemical Property:

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Technology Process of (3R,2'S)-2'-(1-Ethyl-1-methoxy-propyl)-3-((R)-2-nitro-1-phenyl-ethyl)-[1,1']bipyrrolidinyl-2-one

There total 2 articles about (3R,2'S)-2'-(1-Ethyl-1-methoxy-propyl)-3-((R)-2-nitro-1-phenyl-ethyl)-[1,1']bipyrrolidinyl-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

nitrostyrene (5153-67-3) + (S)-2'-(1-Ethyl-1-methoxy-propyl)-[1,1']bipyrrolidinyl-2-one (181293-31-2) → (S)-2'-(1-Ethyl-1-methoxy-propyl)-3-(2-nitro-1-phenyl-ethyl)-[1,1']bipyrrolidinyl-2-one + (3R,2'S)-2'-(1-Ethyl-1-methoxy-propyl)-3-((R)-2-nitro-1-phenyl-ethyl)-[1,1']bipyrrolidinyl-2-one (406497-11-8)

Guidance literature:

(S)-2'-(1-Ethyl-1-methoxy-propyl)-[1,1']bipyrrolidinyl-2-one; With lithium diisopropyl amide; In tetrahydrofuran; at -40 ℃; for 4h;

nitrostyrene; In tetrahydrofuran; at -40 ℃; for 1.5h;

Reference yield:

nitrostyrene (5153-67-3) + (S)-2'-(1-Ethyl-1-methoxy-propyl)-[1,1']bipyrrolidinyl-2-one (181293-31-2) → (3R,2'S)-2'-(1-Ethyl-1-methoxy-propyl)-3-((R)-2-nitro-1-phenyl-ethyl)-[1,1']bipyrrolidinyl-2-one (406497-11-8) + (3S,2'S)-2'-(1-Ethyl-1-methoxy-propyl)-3-((R)-2-nitro-1-phenyl-ethyl)-[1,1']bipyrrolidinyl-2-one

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; at -40 ℃; for 1.5h;

DOI:10.1002/1099-0690(200112)2001:23<4463::aid-ejoc4463>3.3.co;2-t

Reference yield:

(3R,2'S)-2'-(1-Ethyl-1-methoxy-propyl)-3-((R)-2-nitro-1-phenyl-ethyl)-[1,1']bipyrrolidinyl-2-one (406497-11-8) → (3R,2'S)-3-((R)-2-Amino-1-phenyl-ethyl)-2'-(1-ethyl-1-methoxy-propyl)-[1,1']bipyrrolidinyl-2-one

Guidance literature:

With sodium tetrahydroborate; palladium on activated charcoal; In tetrahydrofuran; methanol; at 20 ℃;

upstream raw materials:

nitrostyrene

(S)-2'-(1-Ethyl-1-methoxy-propyl)-[1,1']bipyrrolidinyl-2-one

Downstream raw materials:

[(R)-2-((R)-2-Oxo-pyrrolidin-3-yl)-2-phenyl-ethyl]-carbamic acid tert-butyl ester

{(R)-2-[(3R,2'S)-2'-(1-Ethyl-1-methoxy-propyl)-2-oxo-[1,1']bipyrrolidinyl-3-yl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester

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