4-benzyloxy-3,5-dichloro-N-[2-hydroxy-5-(pyrrolidine-1-sulfonyl)phenyl]benzamide

Base Information

Chemical Name:4-benzyloxy-3,5-dichloro-N-[2-hydroxy-5-(pyrrolidine-1-sulfonyl)phenyl]benzamide
CAS No.:888731-70-2
Molecular Formula:C₂₄H₂₂Cl₂N₂O₅S
Molecular Weight:521.421
Hs Code.:

Synonyms:4-benzyloxy-3,5-dichloro-N-[2-hydroxy-5-(pyrrolidine-1-sulfonyl)phenyl]benzamide

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Chemical Property of 4-benzyloxy-3,5-dichloro-N-[2-hydroxy-5-(pyrrolidine-1-sulfonyl)phenyl]benzamide

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Technology Process of 4-benzyloxy-3,5-dichloro-N-[2-hydroxy-5-(pyrrolidine-1-sulfonyl)phenyl]benzamide

There total 7 articles about 4-benzyloxy-3,5-dichloro-N-[2-hydroxy-5-(pyrrolidine-1-sulfonyl)phenyl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₀H₃₆Cl₂N₂O₅SSi

: 888731-70-2
4-benzyloxy-3,5-dichloro-N-[2-hydroxy-5-(pyrrolidine-1-sulfonyl)phenyl]benzamide

Guidance literature:: C₃₀H₃₆Cl₂N₂O₅SSi; With potassium carbonate; In N,N-dimethyl-formamide; at 0 - 60 ℃; for 1.5h;

With water; citric acid; In N,N-dimethyl-formamide; at 0 ℃;

Reference yield:

: 888731-69-9
2-(tert-butyldimethylsilyloxy)-5-(pyrrolidine-1-sulfonyl)phenylamine

: 354575-15-8
3,5-dichloro-4-benzoxybenzoic chloride

: 888731-70-2
4-benzyloxy-3,5-dichloro-N-[2-hydroxy-5-(pyrrolidine-1-sulfonyl)phenyl]benzamide

Guidance literature:: 2-(tert-butyldimethylsilyloxy)-5-(pyrrolidine-1-sulfonyl)phenylamine; 3,5-dichloro-4-benzoxybenzoic chloride; With pyridine; In dichloromethane; at 0 - 20 ℃;

With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 1.5h;

Reference yield:

: 722464-31-5
2-nitro-4-(pyrrolidine-1-sulfonyl)phenol

: 888731-70-2
4-benzyloxy-3,5-dichloro-N-[2-hydroxy-5-(pyrrolidine-1-sulfonyl)phenyl]benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / palladium-carbon / tetrahydrofuran / 4 h / 0 - 40 °C

2.1: 1H-imidazole / N,N-dimethyl-formamide / 1.5 h / 0 - 40 °C

3.1: pyridine / dichloromethane / 0 - 40 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 1.5 h / 0 - 60 °C

4.2: 0 °C

With pyridine; 1H-imidazole; hydrogen; potassium carbonate; palladium-carbon; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;