4-(3-cyclopentyloxy-4-methoxyphenyl)-4-(fluoromethyl)cyclohexan-1-one dimethyl ketal

Base Information

Chemical Name:4-(3-cyclopentyloxy-4-methoxyphenyl)-4-(fluoromethyl)cyclohexan-1-one dimethyl ketal
CAS No.:153587-29-2
Molecular Formula:C₂₁H₃₁FO₄
Molecular Weight:366.473
Hs Code.:

Synonyms:4-(3-cyclopentyloxy-4-methoxyphenyl)-4-(fluoromethyl)cyclohexan-1-one dimethyl ketal

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Chemical Property of 4-(3-cyclopentyloxy-4-methoxyphenyl)-4-(fluoromethyl)cyclohexan-1-one dimethyl ketal

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Technology Process of 4-(3-cyclopentyloxy-4-methoxyphenyl)-4-(fluoromethyl)cyclohexan-1-one dimethyl ketal

There total 5 articles about 4-(3-cyclopentyloxy-4-methoxyphenyl)-4-(fluoromethyl)cyclohexan-1-one dimethyl ketal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 153587-28-1
4-(3-Cyclopentyloxy-4-methoxyphenyl)-4-(hydroxymethyl)-cyclohexan-1-one dimethyl ketal

: 153587-29-2
4-(3-cyclopentyloxy-4-methoxyphenyl)-4-(fluoromethyl)cyclohexan-1-one dimethyl ketal

Guidance literature:: With (diethylamido)sulfur trifluoride; In dichloromethane; for 0.76h; Ambient temperature;
DOI:10.1021/jm970090r

Reference yield:

: 152630-47-2
4-cyano-4-[3-(cyclopentyloxy)-4-methoxyphenyl]cyclohexan-1-one

: 153587-29-2
4-(3-cyclopentyloxy-4-methoxyphenyl)-4-(fluoromethyl)cyclohexan-1-one dimethyl ketal

Guidance literature:: Multi-step reaction with 4 steps

1: p-TsOH / methanol / 2 h / Heating

2: 96 percent / DIBAL-H / toluene / 2 h / Ambient temperature

3: 79 percent / NaBH₄ / 1,2-dimethoxy-ethane / 0.75 h / Ambient temperature

4: 80 percent / (diethylamido)sulfur trifluoride / CH₂Cl₂ / 0.76 h / Ambient temperature

With sodium tetrahydroborate; (diethylamido)sulfur trifluoride; diisobutylaluminium hydride; toluene-4-sulfonic acid; In methanol; 1,2-dimethoxyethane; dichloromethane; toluene;
DOI:10.1021/jm970090r

Reference yield:

: 153587-34-9
4-(3-cyclopentyloxy-4-methoxyphenyl)-4-formylcyclohexan-1-one dimethyl ketal

: 153587-29-2
4-(3-cyclopentyloxy-4-methoxyphenyl)-4-(fluoromethyl)cyclohexan-1-one dimethyl ketal

Guidance literature:: Multi-step reaction with 2 steps

1: 79 percent / NaBH₄ / 1,2-dimethoxy-ethane / 0.75 h / Ambient temperature

2: 80 percent / (diethylamido)sulfur trifluoride / CH₂Cl₂ / 0.76 h / Ambient temperature

With sodium tetrahydroborate; (diethylamido)sulfur trifluoride; In 1,2-dimethoxyethane; dichloromethane;
DOI:10.1021/jm970090r