(±)-(5Z)-(4-hydroxybenzylidene)-3-(6-hydroxy-2,5,7,8-tetramethylchroman-2-ylmethyl)thiazolidine-2,4-dione

Base Information

Chemical Name:(±)-(5Z)-(4-hydroxybenzylidene)-3-(6-hydroxy-2,5,7,8-tetramethylchroman-2-ylmethyl)thiazolidine-2,4-dione
CAS No.:1448960-24-4
Molecular Formula:C₂₄H₂₅NO₅S
Molecular Weight:439.532
Hs Code.:

Synonyms:(±)-(5Z)-(4-hydroxybenzylidene)-3-(6-hydroxy-2,5,7,8-tetramethylchroman-2-ylmethyl)thiazolidine-2,4-dione

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Chemical Property of (±)-(5Z)-(4-hydroxybenzylidene)-3-(6-hydroxy-2,5,7,8-tetramethylchroman-2-ylmethyl)thiazolidine-2,4-dione

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Technology Process of (±)-(5Z)-(4-hydroxybenzylidene)-3-(6-hydroxy-2,5,7,8-tetramethylchroman-2-ylmethyl)thiazolidine-2,4-dione

There total 4 articles about (±)-(5Z)-(4-hydroxybenzylidene)-3-(6-hydroxy-2,5,7,8-tetramethylchroman-2-ylmethyl)thiazolidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1448960-26-6
(±)-carbonic acid tert-butyl ester 2-[(5Z)-(4-hydroxybenzylidene)-2,4-dioxothiazolidin-3-ylmethyl]-2,5,7,8-tetramethylchroman-6-yl ester

: 1448960-24-4
(±)-(5Z)-(4-hydroxybenzylidene)-3-(6-hydroxy-2,5,7,8-tetramethylchroman-2-ylmethyl)thiazolidine-2,4-dione

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1016/j.ejmech.2014.06.015

Reference yield:

: 123-08-0,65581-83-1
4-hydroxy-benzaldehyde

: 1448960-24-4
(±)-(5Z)-(4-hydroxybenzylidene)-3-(6-hydroxy-2,5,7,8-tetramethylchroman-2-ylmethyl)thiazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 3 steps

1: 3-amino propanoic acid

2: potassium carbonate / N,N-dimethyl-formamide / 48 h / 20 °C / Inert atmosphere

3: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With potassium carbonate; trifluoroacetic acid; 3-amino propanoic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2014.06.015

Reference yield:

: 1375483-11-6
carbonic acid tert-butyl ester 2-hydroxymethyl-2,5,7,8-tetramethyl-chroman-6-yl ester

: 1448960-24-4
(±)-(5Z)-(4-hydroxybenzylidene)-3-(6-hydroxy-2,5,7,8-tetramethylchroman-2-ylmethyl)thiazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / dichloromethane / 0.33 h / 0 °C / Inert atmosphere

2: potassium carbonate / N,N-dimethyl-formamide / 48 h / 20 °C / Inert atmosphere

3: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With pyridine; potassium carbonate; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2014.06.015